Anti-Human C5a/C5a des Arg Monoclonal Antibody (clone 2952) -10 mg (CAT#: CB-P502-K) Datasheet

Antibody

The monoclonal antibody 2952 reacts with a new epitope on C5a (des-Arg), which is formed after the cleavage of C5 into C5a and C5b. C5 participates in the activation of protein pathways in the complement system, which is an important factor in innate immunity. The complement pathway can be divided into activation pathway and lysis pathway. The activation pathway leads to the cleavage of the fifth complement component C5 via C3. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and releases lysosomal enzymes. In addition, C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. Recent studies have shown that by inducing the synthesis of cytokines (such as TNF-αIL-1beta, IL-6 and IL-8), the acute phase response of the liver and the overall immune response can be regulated. General comments: Please note that under given conditions, C5 is known to expose epitopes that are normally only visible in the activated product of cleavage (Reference 5).