BIOBETTER DATABASE

ADCC-Enhanced Antibodies: Maximizing Antibody-Dependent Cellular Cytotoxicity

ADCC-Enhanced antibodies represent a next-generation class of therapeutic antibodies engineered to optimize immune-mediated tumor cell destruction. By leveraging the power of antibody-dependent cellular cytotoxicity (ADCC), these antibodies are specifically designed to engage immune effector cells more effectively, leading to enhanced tumor cell killing.

Key Benefits of Creative Biolabs' ADCC-Enhanced Antibodies:

Enhanced Effector Cell Activation: Reduced fucosylation in the Fc region results in improved binding affinity to FcγR receptors on NK cells, macrophages, and dendritic cells, amplifying ADCC activity.

Superior Antitumor Efficacy: The enhanced ADCC response leads to increased tumor cell lysis, improving therapeutic outcomes in cancer treatment.

Reduced Immune Evasion: These antibodies are engineered to minimize immune escape, providing more durable and effective immune responses.

Customizable Production: We offer tailored solutions based on your therapeutic needs, whether for cancer, infectious diseases, or other immune-related disorders.

Explore Our ADCC-Enhanced Antibody Portfolio

Browse our selection of ADCC-enhanced antibodies, designed to provide superior immune-mediated cytotoxicity. If you need a custom solution or have specific therapeutic requirements, our experts are available to collaborate with you and develop the ideal ADCC-enhanced antibody for your clinical or research applications.

• TargetSelect Target4-1BB4-1BB ligand receptor58P1D125AC5T4A disintegrin and metalloproteinase with thrombospondin motifs 5A33ABCA1ABCB5AbetaAbGn-7ACEAChRAcid-sensing ion channel-1Activated F10Activated F9Activin AActivin BActivin Beta-BACTN4ACVR2AACVR2BACVRL1ADAM15ADAM17ADAM28Adenocarcinoma antigenAdenocarcinoma AntigenAF-20AFPAGR2AGS-16AGS-8ALCAMAlpha EnolaseAlpha toxinAlpha-7 nicotinic receptorAlpha-synucleinAlpha-toxinAMHR2AmphiregulinAmyloid betaAmyloid BetaAnaplastic Lymphoma KinaseAnexelektoAng2Angiopoietin-like protein 3Angiopoietin-like protein 4AngiostatinAngiotensin-II type-I receptorANGPTL3Annexin A1Anthrax Protective antigenAnti-Müllerian hormone receptor type IIAntithrombin BetaAOC3APCDD1APCSApelinApolipoprotein BApolipoprotein C-IIIApolipoprotein EAPPAPRILAQP4Asialoglycoprotein receptorAutotaxinAXLB Cell Receptor ComplexB lymphocyte antigen B7B-lymphocyte antigen CD20B-lymphoma cellB-RafB-type natriuretic peptideB. anthracis PAB. anthrasis PAB7 Related proteinB7-H3B7-H4B7-H6BAFFBAFF ReceptorBAFF-RBAFFRBAG family molecular chaperone regulator 3BARB3BasiginBCMABDCA-2Beta-secretase 1Beta1-ARBFA4BLT2BLySBMP-6BMP9Bone morphogenetic protein receptorBotulinum toxinBR3Bradykinin B2 receptorBSGBST1BST2BTLABTNL9Bv8c-fmsc-Kitc-Metc-METC-X-C motif chemokine 10C. difficile toxin BC1sC242C2orf18C35C3a ReceptorC5C5AR1CA 125CA9Cadherin-1Cadherin-11Cadherin-17Cadherin-19Cadherin-2CADM1Calcitonin gene-related peptide ReceptorCanAgCancer antigen 125Cannabinoid Receptor Type 1Carbonic Anhydrase XIICarcinoembryonic antigen cell adhesion molecule 6Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1Carcinoma associated antigen CTAA16 (complex of cytokeratin polypeptides 35-40kDa)cardiac myosinCathepsin SCaveolin 1CCL11CCL17CCL2CCL21CCL24CCL5CCN1CCR2CCR4CCR5CCR6CCR7CD105CD11aCD123CD140aCD147CD148 receptor tyrosine kinaseCD15CD15/FUT4CD151CD157CD160CD179bCD18CD19CD1dCD2CD20CD200CD200 receptorCD22CD23CD24CD248CD25CD252CD26CD27CD274CD276CD28CD3CD3 epsilonCD3 receptorCD30CD300ACD30LCD32bCD33CD34CD37CD38CD39CD3ECD4CD4 and HIV-1 gp120CD40CD40 (18 Competitor Antibodies)CD40 ligandCD40 LigandCD40LCD41CD44CD44 v6CD45CD46CD47CD48CD5CD51CD51+CD61CD52CD55CD56CD59CD6CD63CD69CD70CD73CD79BCD80CD81CD83CD84CD86CD9CD98CD99CEACEACAM5CEACAM8Cell adhesion molecule 2Cell Death Inducing MoleculeCETPCFBCFDCFR-1CGRPChemokine Beta 4Chemokine receptor CXCR2Chemokine receptor CXCR3Chemokine receptor CXCR4Chordin-like-1Chorionic gonadotropinCitrullinated PeptideCKAP2Clathrin Heavy ChainClaudin 1Claudin 18Claudin-4Claudin-6CLCP1CLDN18.2CLEC12ACLEC14AClever-1ClfAClostridium difficile enterotoxin BClostridium difficile toxin BClusterincMet ReceptorCMVCoagulation Factor XICollagenComplement C2aComplement C3bComplement component 5Connective Tissue Growth FactorCRACCRCPCRTh2CSApCSF1CSF1RCSF2CTAA16.88CTGFCTLA-4CTLA4CUB domain containing protein 1CXC-ELRCXCL10CXCL13CXCR3CXCR4CXCR7Cyclin-dependent kinase 5 activator 1Cytokeratin 8Cytokine Death Receptor 5Cytomegalovirus - unspecifiedCytomegalovirus glycoprotein BCytomegalovirus Glycoprotein BCytotoxic T-Lymphocyte Antigen 4DEC-205Dectin-1Delta like ligand 4Delta-like 1 homologDesmocollin 2DEspRDickkopf-1Discoidin Domain Receptor 2DLL3DLL4DNA/histone H1 complexDNAX Cytokine Receptor Subunit 5DPP4DR3DR5DSG1DSG3E. coli Shiga-like toxin II BE. coli Stx1BE. coli Stx2AEAG1 ion channelEbola Sudan Boniface Virus GlycoproteinEbola virusEbola virus glycoproteinEbola Virus GlycoproteinEbolavirus glycoproteinEBOVEBPHECSCREDA1EDAREGFL7EGFREGFR & cMetEGFR and c-MetEGFR Extracellular Domain IIIEGFR/HER1EGFR/IGF-1REmbiginEMP2EMR1ENDO 180EndosialinEndothelial lipaseEndothelial monocyte activating polypeptide IIendotoxinENGEPCAMEpCAMEPCAM/CD3EPHA10EPHA3EphA3EPHA4EPHA7EphB2EPHB3EphB3EPHB4Epidermal growth factor receptorEpiregulinEPOEPOREquilibrative nucleoside transporter 1ERBB2ERBB2/CD340ERBB3ERG (ETS-related gene)Escherichia coliEstrogen Receptor BetaEstrogen Receptor-alpha 36ETS translocation variant 1Extended Type I glycosphingolipidF3Factor IXaFactor IXa, XFactor VIIIFactor XFAPFas LigandFas ReceptorFatty Acid SynthaseFc alpha receptor (CD89)Fc Gamma Receptor IFc gamma receptor IIIbFc Receptor FcRnFc-epsilon-Receptor IFc-gamma-RIIAFc-gamma-RIIB (CD32b)Fc-gamma-RIIIAFCGRTFcRnFDF03FerritinFerroportinFGF19FGF2FGF21FGF23FGF8FGFR1FGFR2FGFR2bFGFR3FGFR4FibrinFibrin Gamma C domainFibrinogenFibroblast Growth Factor 1fibronectin extra domain-BFibronectin Extra Domain-BFicolin-3FKNFLT1FLT3FMS-like tyrosine kinase-1Fn3folate receptor 1Folate receptor 1FOLH1FOLR1Frizzled 2Frizzled homologue 10Frizzled ReceptorFucosyl GM1FXaFZD1FZD2FZD5FZD7FZD8G-Protein-coupled Receptor 49GAD65Galaninganglioside GD3Ganglioside GD3Ganglioside GM3GAP43GastrinGastrokine 1GCGRGD2GD2 gangliosideGD3 GangliosideGDF-8GDNF family receptor alpha 3Gelatinase BGhrelinGlial fibrillary acidic proteinGLP-1GLP1RGlucagonGlucocorticoid-induced TNF receptor (GITR)Glucocorticoid-induced TNFR-related proteinGlucose regulated protein 78Glucose regulated protein 94Glucose Transporter GLUT8Glucose-dependent insulinotropic polypeptide receptorglycolipidsGlycoprotein transmembrane NMBGlycosphingolipid globotriaosylceramideGlypican 3GM-CSFGM1GM2GM2 GangliosideGMADGMCSF Receptor α-chainGMF-BGolgi protein 73Gonadotropin releasing hormone ReceptorGPC3GPIIb/IIIaGPNMBGPR64GPR87GPRC5DGPVIGranulocyte colony-stimulating factor receptorGranulocyte Macrophage Colony Stimulating FactorGranulysinGremlin 1Growth hormone receptorGRP78GRP94GT468Guanylyl cyclase receptorGUCY2CH7CRHAHBEGFHBsAgHBVHBV Surface AntigenHCMVHDPPA04Heat shock 70kDa protein 9Heat shock protein 27Heat shock protein 90 homologheat shock protein 90 homolog [Candida albicans]Heavily glycosylated mucin-like domain of EBOV glycoprotein (GP)HedgehogHemojuvelinHeparanaseHepatitis BHepatitis B Surfage AntigenHepatitis C virusHepatitis C Virus Core ProteinHepatitis C virus E2 envelope proteinHepatocyte growth/scatter factorHepcidinHepsinHER2HER3Heterogeneous Ribonucleoprotein GHGFHGFAHIG-1High mobility group protein 1HistoneHistone ComplexHistone deacetylase 11Histone H1Histone H2BHistone H4HIV gp41HIV V3HIV-1HLA class IHLA DR betaHLA-B27HLA-DRHLA-DR Beta chainHLA-DR10HM1.24HS6ST2HSP60HSP65HSP90HTRA1Human epidermal growth factor receptor 4IAPPIAV HAIBV HAICAM1ICAM3ICOSICOSLIFN alphaIFN ReceptorIFN-αIFN-α/β receptorIFNA1IFNGIFNγIgEIgE FcIGF-1RIGF1 and IGF2IGF1 ReceptorIGF1+IGF2IGF1RIGF2IGHEIL-12IL-13IL-17IL-17AIL-17FIL-17αIL-1βIL-20RIL-23 p19IL-2RIL-36RIL-3Rα / CD123IL-5IL-5RIL-5R alphaIL-6IL-6 RIL-6RIL-B30IL1IL1 betaIL11RAIL12IL12/IL-23IL12+IL23IL12RB1IL13IL13RA1IL13RA2IL15IL17IL17AIL17FIL17RAIL17RBIL17RCIL17REIL18IL18R1IL19IL1AIL1R1IL1RAPIL1RL1IL2IL20IL22IL23IL23AIL25IL27IL2RIL2RAIL2RBIL31IL31RAIL4IL4RIL5IL5RAIL6IL6RIL7RIL9ILT7Immunoglobulin A1Immunoglobulin germline VH1-69Immunoglobulin-like transcript 3 receptorImmunoglobulin-like transcript 5Influenza A hemagglutininInfluenza H5 HemagglutininING4Insulin ReceptorInsulin-like Growth Factor 1 ReceptorInsulin-like Growth Factor 2Insulin-like Growth Factor Binding Protein 7Insulin-like Growth Factor IIntegrin alpha 10Integrin Alpha 11Integrin alpha 2Integrin alpha 4 beta 7Integrin alpha 5 beta 1Integrin alpha 9Integrin alpha EIntegrin Alpha IIb Beta 3Integrin alpha4 beta7Integrin alphaV beta3Integrin beta 3Integrin Beta 7Integrin beta-2Integrin VLA-1Integrin α4 β7Integrin α5β1Integrin α6β4Integrin α8β1Integrin αIIbβ3Integrin αLIntegrin αvβ3Integrin αvβ5Integrin αvβ6Integrin αvβ8Interferon alphaInterferon alpha receptor 1Interferon gammainterferon α/β receptorInterferon-lambdaInterleukin 10Interleukin 10 Receptor AlphaInterleukin 2Interleukin 20Interleukin 21Interleukin 22Interleukin 22RAInterleukin 23Interleukin 23 p19Interleukin 23 ReceptorInterleukin 3 Receptor Alpha ChainInterleukin 31Interleukin 33Interleukin 34Interleukin 36RInterleukin 8Interleukin-21 ReceptorIRAK4IRTA-2IRTA2IRTA4IRTA5ITGA2ITGA4ITGA4 and ITGB7ITGA4+ITGB7ITGAVITGB2ITGB7JAM-CJAMLJunction adhesion molecule-AKallidinKappa myeloma antigenKC4KDRKIAA1114KID3KIR2DKIR3DKIR3DL2KIRD2KIRD2 subgroupKITKLKB1KLRC1KTPAF50L-plastinL1-CAMLa proteinLabyrinthinLAG-3LAG3Laminin ReceptorLaminin-332Laminin-5 alpha 3Lecithin:cholesterol acyltransferaseLectin 2Lectin-like transcript 1Leukocyte receptor tyrosine kinaseLewis YLFL2LGR7LIGHTLINGO-2LINGO1LIV-1LOXL2LRP5LRP6LRR and Ig domain 'containing, Nogo receptor' interacting proteinLRRC15LSRLTALymphocyte Activation Gene 3Lymphocyte antigen 6ELymphotoxin alphaLymphotoxin beta receptorlymphotoxin-alphaLYPD3Lysophosphatidic acidLysosomal-associated membrane protein 1Lysosomal-associated membrane protein family, member 5M2eMac-2-binding proteinMacrophage Colony Stimulating Factor 1Macrophage inhibitory cytokine 1Macrophage mannose receptor 1Macrophage migration inhibitory factorMADCAM1MAGMAGEA3Magic Roundabout (mr)Major histocompatibility complexMASP-2MASP2Matrix metalloproteinase 13Matrix metalloproteinase 14Matrix metalloproteinase 8Matrix Metalloproteinase-12Matrix metalloproteinase-9MCAMMCP-1MCP-3MCSPMDL-1Melanocortin-4 receptormelanotransferrinMesothelinMETMHC class I chain-related protein AMHC class I polypeptide-related sequence BMICAMicrofibrillar-associated protein 4MidkineMIFMilk fat globule-EGF factor 8 proteinMinichromosome maintenance protein 6Minichromosome maintenance protein 7MMP9MP1MRP3MS4A1MSLNMSPMST1RMSTNMUC1MUC1 (Mucin1)MUC16MUC18MUC5ACMucin 17Mucin 5ACMucosal addressin cell adhesion moleculeMyeloproliferative leukemia virus oncogeneMyocyte-specific enhancer factor 2CMyotubularin 1N2 self-peptideNaPi2bNAv1.7NCA-90NCAM1Nectin-2Nerve growth factorNerve growth factor 2Nesfatin-1NeublastinNeuregulin 1Neurokinin BNeuropeptide WNeuropeptide YNeuropilin-1Neuropilin-2Neurturin receptor-ANeutrokine-alphaNeutrophil gelatinase-associated lipocalinNGCGM3NGFNicastrinNIKNKG2ANKG2DNogo receptor-1Nogo-66 receptorNogo-ANon-receptor tyrosine-protein kinase TNK1NonoNotch ReceptorNOTCH1Notch1NOTCH2Notch2Notch3Notum pectinacetylesteraseNR10NRP1NRXN1NT5ENuclear Factor Kappa-B inhibitor betaNY-ESO-IOncostatin MOrai1OSCAROsteonectinOsteopontinOsteoprotegerin binding proteinOvr110Ovr115Ovr232v3OX40OX40 ReceptorOxidized LDLoxLDLP-selectinP-selectin glycoprotein ligand-1P. aeruginosa Serotype IATS O11p28GANKp53 apoptosis effector related to PMP-22PAPAC1PAD2PAI-1PALPPAMPPancreatic adenocarcinoma upregulating factorParathyroid hormoneParathyroid hormone related proteinPCSK9PD-1PD-1 & LAG-3PD-L1PD-L1 & CTLA-4PD-L1 & TGFβPDCD1PDGF-DPDGF-R alphaPDGFBPDGFRAPDGFRBPECAM1Peptidase inhibitor 16Peptidoglycan recognition protein 1PeriostinPF4PGFPhosphatidylserinePhospholipase A2Phospholipase D4PhosphorylcholinePIVKA-IIPlasma kallikreinPlasmalemma vesicle-associated proteinPlatelet Activating FactorPlatelet-derived growth factor CPleiotrophinPMEL17PMSAPodocalyxin-like protein 2PolyubiquitinPotassium voltage-gated channel, shaker-related subfamily, member 3Presenilin 1Presenilin 2PRG-3PRLRPro104Pro108PRO286ProgastrinProgrammed Cell Death 1 Ligand 2ProgranulinProkineticin receptor 1Prominin-1ProperdinProprotein Convertase Subtilisin/Kexin Type 9Prostaglandin E2Prostaglandin E2 receptor subtype EP4Prostate Cancer Lipid-like AntigenProstate Stem Cell AntigenProstate-specific antigenProtease activated receptor 2Protease-activated receptor 1Protein CProtein C InhibitorProtein tyrosine kinase 7Protein tyrosine phosphatase betaProtein tyrosine phosphatase SigmaProvasopressinPseudomonas aeruginosa PvrV proteinPseudomonas Aeruginosa Type IIIPSKPSMAPTK7Purinergic (P2X) receptor 7PVRL4Pyk-2R-Spondin 1RAAG12Rabies virusRabies Virus G GlycoproteinRabies Virus GlycoproteinRAGERas homolog gene family, member BReceptor activity modifying protein-3Receptor tyrosine kinase-like orphan receptor 1Receptor tyrosine-protein kinase erbB-3Related to receptor tyrosine kinaseRELPrespiratory syncytial virusRespiratory Syncytial VirusRespiratory Syncytial Virus F proteinRG1RGM ARGMARh blood group, D antigenRHDRhesus (Rh)DRon ReceptorRoot Plate-specific Spondin 3ROR1RSPO3RSVRSV FRSV-GRSVFRRTN4Rubella VirusS. aureusS. epidermidis LTAS.aureus ABC transporterS100 calcium binding protein BS100A4S100A9S1PSARS-CoV-2SARS-CoV-2 RBDSclerostinSDC1SEBSecreted frizzied related protein 5Secreted frizzled related protein type 4Secreted phospholipase A2-VSecretory leukocyte protease inhibitorSeizure protein 6 homologselectin PSelectin PSELLSELPSEMA3ASemaphorin 4ASemaphorin 4BSemaphorin 4DSerotransferrinSerum AlbuminSerum Amyloid ASerum Amyloid PShiga toxin (E. coli)Sialic acid immunoglobulin-like lectins (Siglec)-8Sialoadhesin factor-3Sialyltetraosyl carbohydrateSiglec-15Siglec-8Signal peptide-containing proteinsSignal-regulatory protein alphaSLAM family member 7SLAMF7SLAMF7/ CS1SLC34A2SLITRK6SM5-1SNCASodium channel subunit beta-2Somatostatin receptorSortilinSOSTSphingosine-1-phosphatesPLA2-IIAsPLA2-XStaphylococcus aureusStaphylococcus aureus alpha toxinSTEAP-1STEAP1STOP-1STRO-1Stromal cell-derived factor-1 alphaSuperoxide dismutase type 1SynaptophysinSyndecan 1System ASC amino acid transporter 2T Cell ReceptorT-cell immunoglobulin and mucin domain containing molecule-3T-cell surface glycoprotein CD3 epsilon chainTACITAG-72TAG72TAT188TAT194TAT211TAT226TAT419TAT425TATA-binding protein-associated factor 15TauTau proteinTCRTDP-43TEM8Tenascin CTenascin C/TNCTeneurin M4TERTTFF1TFPITG2TGF beta 2TGF-βTGF3TGFB1TGFB2Th17TH2AF1ThrombinThymic Stromal LymphopoietinThyroid stimulating hormone (TSH) receptorTie-1 receptorTIE-2TIGITTIM-1TIM-3TIMP1TIP-1TIRC7Tissue FactorTissue factorTissue factor pathway inhibitorTL1aTL5TM4SF20TM4SF5TMEFF2TMEM27TMPRSS11ETMPRSS2TNCTNC A2 DomainTNFTNF receptor 1TNF receptor-related protein TR2TNF-alphaTNF-αTNFRSF10ATNFRSF10BTNFRSF12ATNFRSF4TNFRSF8TNFRSF9TNFSF11TNFSF12TNFαToll-like receptor 2Toll-like receptor 3Toll-like receptor 4toxin A [C. difficile]TR6TRAIL Receptor-1TRAIL-R4Transcobalamin ReceptorTransferrin receptorTransforming growth factor alphaTransforming growth factor betaTransforming growth factor beta receptor IITransmembrane protein 16ATransmembrane protein 30ATRAPTREM-1Trio Rho guanine nucleotide exchange factorTrkBTrkCTROP-2Troponin ITSG101TSLPTSLPRTSPAN8Tudor domain-containing protein 3Tumor endothelial marker 7-related precursorTumor necrosis factor receptor superfamily member 21Tumor necrosis factor receptor TR9Tumor necrosis factor-alphaTumor-associated glycoprotein 72tumour associated glycoprotein 72TWEAKTWEAK ReceptorTyrosine receptor kinase Atyrosyl-tRNA synthetaseTYRP1Unc5BUrokinase-type plasminogen activatorUroplakin 1bVaccinia VirusVascular Adhesion Protein VAP-1Vascular endothelial growth factor (22 Competitor Antibodies)Vascular endothelial growth factor AVasohibin 2VE-cadherinVEGFVEGF Receptor 2VEGF-AVEGF-CVEGF-DVEGFAVEGFR-2 Kinase insert domain receptorVEGFR-3VEGFR2VIMVimentinVISTAVoltage-dependent calcium channel subunit alpha-2/delta-1Von Willebrand FactorVPAC1 ReceptorWest Nile Virus Envelope ProteinWilms tumor proteinWISEXCR1Zaire Ebolavirus GlycoproteinZika virusZNRF3 E3 ubiquitin ligaseα4β7 integrinαVβ3 integrinβ-amyloidβ-amyloid (1-40 and 1-42)
• IsotypeSelect Isotype[(scFv - heavy - kappa) - IGHE - CH4]2[V-kappa]2 - Fc& IgGCamel IgGChicken IgYChimeric IgGCow IgGF(ab')2 - G3 - kappaFab - G1 - kappaFv - disulfide stabilizedHumanized IgGHumanized IgG1IgEIgGIgG1IgG1 ADCIgG1 FabIgG1 with low fucose contentIgG1 κIgG1, low fucose contentIgG1, κIgG1, λIgG1, λ1IgG1, λ2IgG1/3IgG1
  heavy chains and kappa light chainsIgG1kIgG1κIgG2IgG2 / G4, κIgG2, κIgG2, κ, λIgG2, λIgG2/4IgG2aIgG2a / G2bIgG2a, κIgG2aκIgG2bIgG2b, κIgG2b,KIgG2kIgG2κIgG2λIgG3IgG3, κIgG4IgG4, bispecificIgG4, κIgG4, λIgGIIgMIgM, κIgYlgG2lgG2aMouse IgGscAbscFvscFv - heavy - kappascFv, kappaTherapeutic AntibodyVH - C-kappa - CH2 - CH3 _ V-lambda - CH1 _ H-GAMMA-1 _ L-kappaVH - V-kappa - CH2 - CH3