Therapeutic Antibody Engineering Overview
Therapeutic antibodies play a critical role in modern medicine, offering targeted treatments for a range of diseases. With competition in the field increasing, the cost of developing successful antibodies is also on the rise. Hence, the quest to discover innovative strategies that enhance the safety, effectiveness, and production feasibility of antibody candidates serves as a pivotal endeavor in the streamlined advancement of therapeutic antibodies.
Fig. 1 IgG antibodies' effector functions.1,2
Therapeutic Antibody Engineering Service at Creative Biolabs
As an industrial leader in the antibody engineering field, Creative Biolabs is proud to globally deliver an integrated therapeutic antibody engineering service for boosting customers' antibody research into the market. Together with our experienced scientists and cutting-edge technologies, Creative Biolabs is committed to working closely with you to optimize the therapeutic antibody engineering process and achieve the specific product profile and endpoints you are aiming for in your antibody therapy.
Fig. 2 Development process of therapeutic antibodies.
Before progressing to clinical trials, therapeutic antibody candidates typically go through several stages of research and development. These include initial antibody discovery and screening processes focused on antigen binding ability evaluation, lead selection based on biological activity, and lead optimization to improve safety, efficacy, and manufacturability. According to that, we provide a series of services as follows to discover and develop antibodies with good performance.
Nonhuman antibody's immunogenicity is easy to induce anti-drug antibody generation in humans. It is necessary to reduce their immunogenicity to reach a better therapeutic degree. Creative Biolabs provides an antibody safety-enhanced engineering service that targets antibody humanization, deimmunization, and immune-tolerization induction. Our complete engineering system will enable customers to obtain antibodies with excellent safety.
Enhancing the efficacy of antibodies is a key step in antibody optimization. Creative Biolabs' antibody efficacy-enhanced engineering service provides diverse effective pathways such as Fc engineering and glycosyl modification to achieve superior affinity and specificity. Backed up by state-of-the-art technologies and a wealth of expertise, our team enables your unique requirements to be satisfied and desirable outcomes to be presented in a timely manner.
Antibody developability is another optimization priority in addition to safety and efficacy. Desirable therapeutic antibodies should be characterized by lower clearance, lower heterogeneity, higher thermostability, higher solubility, and higher chemical stability. Our antibody developability-enhanced engineering service has great potential to incorporate these good performances into your antibody development.
Cutting-edge Technologies at Creative Biolabs
We offer various top-ranking technologies to design for global customers' significant projects:
Features of Our Therapeutic Antibody Engineering Service
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Extensive abilities in antibody development and engineering.
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Ph.D. research team enables our therapeutic antibody engineering service.
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State-of-the-art technologies aid in project success.
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Complete solution options along the discovery and development spectrum.
If you want to get more information about our therapeutic antibody engineering service, please feel free to contact us.
References
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Kang, Tae Hyun, and Sang Taek Jung. "Boosting therapeutic potency of antibodies by taming Fc domain functions." Experimental & molecular medicine 51.11 (2019): 1-9.
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Distributed under Open Access license CC BY 4.0, without modification.
All products and services are for Research Use Only. Do Not use in humans.
