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Antibody-dependent cellular cytotoxicity (ADCC)-enhanced antibody removes core fucose from the sugar chain of the antibody, thereby enhancing the binding force of the antibody to the Fc receptor FcγIIIa (CD16a), increasing ADCC, and the antibody shows higher clinical efficacy effect. Creative Biolabs provides a series of ADCC/CDC enhanced antibody production and analysis services, bringing reliable support and accurate results to your project.

Fig. 1 IgG structure and its binding regions. (Saxena and Donghui, 2016) Therapeutic Fc Characterization Services
Creative Biolabs offers a diverse portfolio of Fc functional characterization services. In particular, we offer cell-based functional assays for evaluating antibody effector functions and/or Fc engineering services for antibody function regulation.

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Fig. 2 Monoclonal antibody and N-glycosylation sites on it. (Liu, et al., 2017) Therapeutic Antibody Glycan Characterization
Creative Biolabs introduces a streamlined, end-to-end analytical platform for characterizing glycosylation profiles of therapeutic monoclonal antibodies (IgG1). In this platform, we use new column technology and high-resolution mass spectrometers to simplify sample preparation procedures. The analytes were then studied HILIC-UPLC/FLR/MS and the resulting data were analyzed to obtain glycosylation profile information in the Fc region to further characterize IgG1 heterogeneity.

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Fig. 3 Stable cell line generation. (Szczesny, et al., 2018) Stable Cell Line Service
Creative Biolabs successfully established stable FUT8−/−-CHO cell lines for ADCC antibody production, Fucoanalog™ cell lines, and Glymax™ cell lines. In particular, our stable cell lines can be used for ADCC/CDC assay development, ADCC/CDC functional studies, and more.

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Fig. 4 The Fc region of an antibody mediates effector functions such as CDC and ADCC. (Saeed, et al., 2017) Therapeutic ADCC/CDC Antibody Production and Analysis
After your projects move to ADCC/CDC optimization, experts at Creative Biolabs show you how to accelerate the development, unleash your ADCC/CDC-enhanced antibody, and perform highly accurate and reliable ADCC/CDC analysis.
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Fig. 5 ADCC/CDC. (Verhoeven, et al., 2018) ADCC/CDC Antibody Process Development
Creative Biolabs provides upstream and early downstream development ADCC/CDC enhanced therapeutic antibody services to provide powerful, high-yield antibody products for your scientific research needs.

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Fig. 6 cGMP ADCC/CDC⁺ Antibody Manufacturing. (Creative Biolabs) cGMP ADCC/CDC Antibody Manufacturing
Creative Biolabs offers an appropriate solution for ADCC/CDC-enhanced cGMP manufacturing needs. Our proprietary CHO stable cell line platform enables us to provide you with high yields, traceable, and consistent GMP protein in a variety of batches. Every step of our manufacturing process meets global standard quality control guidelines.

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Benefits of Our Services

Through our expertise in antibody manufacturing and state-of-the-art technology and instrumentation, Creative Biolabs is committed to providing customers with the best ADCC/CDC antibody engineering services and ensuring that every step of the process meets your requirements. If you are interested, please feel free to contact us.


  1. Saxena, Abhishek, and Donghui Wu. "Advances in therapeutic Fc engineering–modulation of IgG-associated effector functions and serum half-life." Frontiers in immunology 7 (2016): 580.
  2. Liu, Sheng, et al. "Comprehensive N-glycan profiling of cetuximab biosimilar candidate by NP-HPLC and MALDI-MS." PloS one 12.1 (2017): e0170013.
  3. Szczesny, Roman J., et al. "Versatile approach for functional analysis of human proteins and efficient stable cell line generation using FLP-mediated recombination system." PloS one 13.3 (2018): e0194887.
  4. Saeed, Abdullah FUH, et al. "Antibody engineering for pursuing a healthier future." Frontiers in microbiology (2017): 495.
  5. Verhoeven, Dorit, et al. "Increased risk of hematologic malignancies in primary immunodeficiency disorders: opportunities for immunotherapy." Clinical Immunology 190 (2018): 22-31.


Creative Biolabs provides luciferase-based ADCC assay. This Jurkat cell based assay is pioneered by Creative Biolabs, and the methodology is very well accepted by the field. See attached ADCC Reporter Assay Protocol for further details. 

All products and services are for Research Use Only. Do Not use in humans.


ADCC Assay WT vs AfucoTM Mabs  Visit


Antibody Fc Engineering: Towards Better Therapeutics  Visit


Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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