Complement Component Assay Services

At a glance

The complement system is composed of a large number of plasma proteins, which help or supplement the ability of phagocytes and antibodies to eliminate pathogens. There are three pathways for complement activation, namely the classic pathway, the alternative pathway and the recently discovered MBL- lectin pathway. Further research on the complement system has focused on specific complement components. For example, C4d, a product of the classical and lectin pathway, was considered a biomarker in the 1990s due to its stability and strong association with antibody-mediated rejection. In the past two decades, the potential importance of C4d as a tool to diagnose and monitor SLE in systemic lupus erythematosus (SLE) has also been emphasized. As another example, complement factor H (CFH) is the first regulatory protein of the alternative pathway of the complement system. Genetic analysis shows that there is a clear link between CFH and different human diseases, including kidney disease, atypical forms of hemolytic uremic syndrome (aHUS) and membranous proliferative glomerulonephritis (MPGN), and age-related Macular degeneration (AMD) of the eye.

Complement Component Assay Services

Creative Biolabs has developed a standardized detection method for each complement protein without cross-reacting with its related complement protein. We also provide a complement panel that depends on the customizable selection of the analyte, such as C2, C4b, C5, C5a, C9, factor D, MBL and factor I.

We have rich experience and reliable records

The complement system is an integral part of the innate immune response. Considering the important role of complement activation research in many human diseases, it is important in a wide range of applications-from drug development and medical device safety to clinical diagnosis and basic research.

Creative Biolabs has more than 10 years of experience in complement system analysis and development. Our complement system assays are developed by our experienced scientists and can produce sensitive, reliable and easy-to-use products for exploring most aspects of the complement system.

Featured Assay Component

  • C3A Complement Activation Assay Services
  • Complement Fixation (CF) Assay
  • Complement C3 and C4 Measurements
  • Complement Activity Biomarkers
  • C3b Deposition Assay
  • ADAMTS-13 Activity
  • Alternative Pathway Functional Assay
  • C3 Nephritic Factor/C5 Nephritic Factor/Nef Activity
  • C4 Nephritic Factor
  • Complement C3 Plasma Level
  • Complement CH50eq Assay
  • Factor B Autoantibody Test
  • Factor H Autoantibody Test
  • Hemolytic Assays of Complement Activity
  • Human Complement Ba Fragment Assay
  • Human Complement Bb Fragment Level Assay
  • Human Complement C3c Fragment Assay
  • Human Complement C4 Level Assay
  • Human Complement C5 Level Assay
  • Human Complement Factor B Level Assay
  • Human Complement Factor I Assay
  • Human Factor H Assay
  • Human Plasma Properdin Level Assay
  • Soluble C5b-9 Assay

For more detailed information, please feel free to contact us or directly sent us an inquiry.

RESOURCES

Creative Biolabs provides luciferase-based ADCC assay. This Jurkat cell based assay is pioneered by Creative Biolabs, and the methodology is very well accepted by the field. See attached ADCC Reporter Assay Protocol for further details. 

All products and services are for Research Use Only. Do Not use in humans.

CASE STUDY

ADCC Assay WT vs AfucoTM Mabs  Visit

Resource

Antibody Fc Engineering: Towards Better Therapeutics  Visit

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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