The complement system is composed of a large number of plasma proteins, which help or supplement the ability of phagocytes and antibodies to eliminate pathogens. There are three pathways for complement activation, namely the classic pathway, the alternative pathway and the recently discovered MBL- lectin pathway. Further research on the complement system has focused on specific complement components. For example, C4d, a product of the classical and lectin pathway, was considered a biomarker in the 1990s due to its stability and strong association with antibody-mediated rejection. In the past two decades, the potential importance of C4d as a tool to diagnose and monitor SLE in systemic lupus erythematosus (SLE) has also been emphasized. As another example, complement factor H (CFH) is the first regulatory protein of the alternative pathway of the complement system. Genetic analysis shows that there is a clear link between CFH and different human diseases, including kidney disease, atypical forms of hemolytic uremic syndrome (aHUS) and membranous proliferative glomerulonephritis (MPGN), and age-related Macular degeneration (AMD) of the eye.
Creative Biolabs has developed a standardized detection method for each complement protein without cross-reacting with its related complement protein. We also provide a complement panel that depends on the customizable selection of the analyte, such as C2, C4b, C5, C5a, C9, factor D, MBL and factor I.
The complement system is an integral part of the innate immune response. Considering the important role of complement activation research in many human diseases, it is important in a wide range of applications-from drug development and medical device safety to clinical diagnosis and basic research.
Creative Biolabs has more than 10 years of experience in complement system analysis and development. Our complement system assays are developed by our experienced scientists and can produce sensitive, reliable and easy-to-use products for exploring most aspects of the complement system.
For more detailed information, please feel free to contact us or directly sent us an inquiry.
Creative Biolabs provides luciferase-based ADCC assay. This Jurkat cell based assay is pioneered by Creative Biolabs, and the methodology is very well accepted by the field. See attached ADCC Reporter Assay Protocol for further details.
All products and services are for Research Use Only. Do Not use in humans.
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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.