Complement Component Assay Services

At a glance

The complement system is composed of a large number of plasma proteins, which help or supplement the ability of phagocytes and antibodies to eliminate pathogens. There are three pathways for complement activation, namely the classic pathway, the alternative pathway and the recently discovered mannose-binding lectin (MBL)- lectin pathway. Further research on the complement system has focused on specific complement components. For example, C4d, a product of the classical and lectin pathway, was considered a biomarker in the 1990s due to its stability and strong association with antibody-mediated rejection. In the past two decades, the potential importance of C4d as a tool to diagnose and monitor SLE in systemic lupus erythematosus (SLE) has also been emphasized. As another example, complement factor H (CFH) is the first regulatory protein of the alternative pathway of the complement system. Genetic analysis shows that there is a clear link between CFH and different human diseases, including kidney disease, atypical forms of hemolytic uremic syndrome (aHUS) and membranous proliferative glomerulonephritis (MPGN), and age-related Macular degeneration (AMD) of the eye.

Fig.1 Activation of the complement system.^{1, 2}

Creative Biolabs has developed a standardized detection method for each complement protein without cross-reacting with its related complement protein. We also provide a complement panel that depends on the customizable selection of the analyte, such as C2, C4b, C5, C5a, C9, factor D, MBL and factor I.

We have rich experience and reliable records

The complement system is an integral part of the innate immune response. Considering the important role of complement activation research in many human diseases, it is important in a wide range of applications-from drug development and medical device safety to clinical diagnosis and basic research.

Creative Biolabs has more than 10 years of experience in complement system analysis and development. Our complement system assays are developed by our experienced scientists and can produce sensitive, reliable and easy-to-use products for exploring most aspects of the complement system.

Featured Assay Component

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References

1. Kraiczy, Peter. "Travelling between two worlds: complement as a gatekeeper for an expanded host range of Lyme disease spirochetes." Veterinary Sciences 3.2 (2016): 12.
2. under Open Access License CC BY 4.0, without modification.