Anti-Human CD59 Monoclonal Antibody (clone MEM-43) -10 mg (CAT#: CB-P485-K) Datasheet

Antibody

This antibody is the prototype antibody of the CD59 determinant, which is an 18-25 kDa PI-linked glycoprotein, which is widely expressed in most types of cells. Antigens are the main complement protection molecules of human cells. It is expressed on all white blood cells, red blood cells and most other cell types. The binding of this antibody inhibits the complement protective activity of CD59. CD59 is one of the complement regulatory membrane proteins missing in paroxysmal nocturnal hemoglobinuria (PNH). The anti-CD59 reagent can be used for the differential diagnosis of type II PNH and type I PNH. Recently, the role of CD59 in LPS signal transduction has been reported in keratinocytes. The antibody reacts with a well-defined epitope (W40, R-53) on the CD59 molecule.