Book a Meeting

Antibody Developability-enhanced Engineering Services

Overview of Antibody Developability-enhanced Engineering

Therapeutic antibodies have revolutionized the treatment of various diseases by targeting specific molecules involved in the disease process. However, their development may be challenging, especially at high concentrations, due to issues like self-association, viscosity, and phase separation. As a result, improving the developability of therapeutic antibodies is of great importance to enhance their efficacy and safety in clinical settings.

The evolution of Fc-engineered therapeutic antibodies marks a new era in antibody treatment modalitiesFig. 1 The human IgG antibody's basic structure.1

Antibody Developability-enhanced Engineering Service at Creative Biolabs

At the early phase of therapeutic antibody development, it is important to enhance their developability for better antibody properties. Based on our expertise and experience in antibody engineering, Creative Biolabs delivers a cost-effective antibody developability-enhanced engineering service to support global customers' significant projects.

Within the engineering process, we are able to enhance and assess the developability profile of your antibody in the initial stages to provide the most effective antibody sequence. Simultaneously, we provide various rapid and high-throughput approaches (i.e. computer-aided molecular design, blotting, flow cytometry.) to screen the optimal antibodies. At Creative Biolabs, our experienced scientists offer customized strategies to minimize risk and enhance the success of your antibody development efforts, ensuring optimal outcomes in clinical settings.

In addition, our service focuses on pharmacokinetic improvement and pharmaceutical property development of therapeutic antibodies, which includes the following:

Enhancing the pharmacokinetics of a therapeutic antibody can lead to reduced dosages, the possibility of developing a subcutaneous formulation, and ultimately lowering the overall cost. The main mechanisms by which therapeutic antibodies are cleared from the body include nonspecific clearance and antigen-binding mediated clearance. According to that, Creative Biolabs delivers a service to improve therapeutic antibodies' pharmacokinetics by reducing the two causes, including:

Reduction of non-specific clearance

Reduction of antigen binding-mediated clearance

Low thermostability, low solubility, low chemical stability, and high heterogeneity are important inducers that cause low biological activity and easy aggregation of therapeutic antibodies, which greatly improve the immunogenicity of therapeutic antibodies and affect their therapeutic efficacy. Creative Biolabs' antibody pharmaceutical property development service has the potential to act as an effective tool to optimize these properties, thereby improving the chances of successful antibody development for our customers. The following are several strategies we utilize:

Improvement of thermostability

Improvement of solubility

Improvement of chemical stability

Reduction of heterogeneity

Benefits for You

Frequently Asked Question

Q1: Is it necessary to utilize structure-based design in antibody engineering and evaluate its developability?

A1: Computational antibody design methods have revolutionized therapeutic discovery by offering a cost-effective and efficient solution. Accurate antibody structure models play a crucial role in estimating developability parameters, paired with the growing availability of antibody sequences. This enables large-scale structural antibody virtual screening, making structure-based design essential in antibody engineering and developability assessment.

If you are interested in our antibody developability-enhanced engineering service, please reach out to us with your projects.


  1. Wang, Bo, et al. "Optimization of therapeutic antibodies." Antibody therapeutics 4.1 (2021): 45-54.


Creative Biolabs provides luciferase-based ADCC assay. This Jurkat cell based assay is pioneered by Creative Biolabs, and the methodology is very well accepted by the field. See attached ADCC Reporter Assay Protocol for further details. 

All products and services are for Research Use Only. Do Not use in humans.


ADCC Assay WT vs AfucoTM Mabs  Visit


Antibody Fc Engineering: Towards Better Therapeutics  Visit


Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *