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Antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) are not only the main ways for the body to clear cells infected by viruses or other pathogens through antibodies but also one of the mechanisms of action of current antibody drugs to exert clinical effects. Monoclonal antibody drugs link targeted therapy and immunoactivation therapy, bringing profound changes to the treatment of cancer. In particular, in ADCC, the Fab fragment of the antibody can target tumors, infected cells, or free pathogens, and its Fc fragment can bind to FcγR, which has effector activity, making it have strong immunological activity. Creative Biolabs develops multiple ADCC/CDC platforms to facilitate your research projects:

Fig. 1 Antibody-dependent cellular cytotoxicity (ADCC). (Ma, et al., 2020) ADCC Enhancement Technology
Creative Biolabs provides proprietary ADCC enhancement technology to help you target different diseases of your interests and accelerate your research. We have different platforms for your project to meet your different needs, including Afuco™, Glymax™, Fucoanalog™, Fc Protein-Engineering, Cross-Isotype Engineering, CD16A Bispecific Antibody Engineering, and Glyco- and Fc Protein Dual Engineering.

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Fig. 2 Complement-dependent cytotoxicity (CDC). (Zent, et al., 2020) CDC Enhancement Technology
Creative Biolabs is committed to developing and promoting the field of CDC-enhanced antibodies. In this section, we have proprietary CDC⁺ antibody platform, including Crea-Tag™, Fc Protein Engineering, and Crosstype™ Engineering, which allows antibody conversion with limited or no chance to mutate to other potent cytotoxic antibodies.

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Fig. 3 Antibody-dependent cellular cytotoxicity (ADCC) and Complement-dependent cytotoxicity (CDC). (Barth and Stanton, 2019) Dual ADCC/CDC Enhancement Technology
With a dedicated team and its advanced knowledge of ADCC/CDC enhancement technology, Creative Biolabs integrates ADCC and CDC dual enhancement modifications into a single antibody platform, providing a proprietary ADCC/CDC⁺ dual antibody platform for the design and development of dual ADCC/CDC enhanced antibodies with enhanced ADCC and CDC activity.

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Fig. 4 The schematic of overall IgG structure. (Saxena and Donghui, 2016) Therapeutic Fc Engineering Technology
Crystallizable region (Fc) enhances the efficacy of monoclonal antibodies by functioning such as ADCC, ADCP, and CDC. Creative Biolabs is committed to the design of Fc receptor-IgG interacting biologics. We offer you a variety of innovative Fc modification strategies to facilitate your projects.

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Fig. 5 Schematic overview of human IgG1. (Lippold, et al., 2019) Therapeutic Antibody Glycosylation Engineering Technology
Creative Biolabs develops engineered Fc glycosylation to produce therapeutic monoclonal antibodies with desired properties to enhance the function and efficacy of therapeutic IgG antibodies. We developed multiple glycan engineering strategies to reduce mAb glycan heterogeneity to improve the safety and therapeutic efficacy of these important drugs.

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With a professional team of experts who have a deep understanding of ADCC and advanced instruments and equipment, Creative Biolabs offers you full-scale technology services for your ADCC project. We are pleased to discuss our knowledge about your current problems and propose solutions to meet your requirements. Please do not hesitate to contact us.


  1. Ma, Bo, et al. "Protein glycoengineering: An approach for improving protein properties." Frontiers in Chemistry 8 (2020): 622.
  2. Zent, Clive S., et al. "Complement activation in the treatment of B-cell malignancies." Antibodies 9.4 (2020): 68.
  3. Barth, Matthew J., and Stanton C. Goldman. "Resistance to Monoclonal Antibody Therapeutics in Lymphoma." Resistance to Targeted Therapies in Lymphomas (2019): 27-55.
  4. Saxena, Abhishek, and Donghui Wu. "Advances in therapeutic Fc engineering–modulation of IgG-associated effector functions and serum half-life." Frontiers in immunology 7 (2016): 580.
  5. Lippold, Steffen, et al. "Proteoform-resolved FcɤRIIIa binding assay for fab glycosylated monoclonal antibodies achieved by affinity chromatography mass spectrometry of Fc moieties." Frontiers in Chemistry 7 (2019): 698.


Creative Biolabs provides luciferase-based ADCC assay. This Jurkat cell based assay is pioneered by Creative Biolabs, and the methodology is very well accepted by the field. See attached ADCC Reporter Assay Protocol for further details. 

All products and services are for Research Use Only. Do Not use in humans.


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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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