Anti-Mouse C3aR Monoclonal Antibody (clone 14D4) -0.5 mg (CAT#: CB-P382-K) Datasheet

Antibody

The monoclonal antibody 14D4 reacts with mouse C3aR, which is a member of the 7 transmembrane G protein-coupled receptor rhodopsin superfamily, with a molecular weight of approximately 54 kDa. The expression of C3aR has been confirmed on a variety of immune cells, including monocytes, macrophages, dendritic cells, neutrophils, basophils, eosinophils, mast cells, T lymphocytes And B lymphocytes. In addition, C3aR is found on cells of the central nervous system, lungs and kidneys. In the process of complement activation, C3aR acts as the cell surface receptor of C3a, which is the C-terminal 77 amino acid cleavage product of C3. C3a has allergic toxicity and immunomodulatory properties, such as smooth muscle contraction, mast cells release histamine and enhanced vascular permeability. In addition, C3a induces the respiratory burst of neutrophils, and has the chemotactic properties of eosinophils and mast cells. In addition, C3a leads to the release of key cytokines from multiple cell types, including IL-1β, TNF-α, IL-6 and IL-8. The role of C3aR has been implicated in several murine disease models. Studies have shown that C3aR inhibition can reduce neurodegeneration in experimental lupus, and in the murine model of allergic airway disease, the lack of C3a receptors can prevent changes in lung physiology after allergen challenge. Finally, it has been shown that loss of C3aR is protective in experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein.