Description
Anti-CD38 Antibody, Non-Fucosylated (BioBet-017ZP) is a human monoclonal IgG antibody against CD38. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Multiple Myeloma (MM)
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CD38 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD38
Full Name
platelet derived growth factor receptor alpha
Background
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
Alternative Names
Platelet Derived Growth Factor Receptor Alpha; Platelet-Derived Growth Factor Receptor, Alpha Polypeptide; Alpha-Type Platelet-Derived Growth Factor Receptor; Platelet-Derived Growth Factor Receptor 2; CD140 Antigen-Like Family Member A; CD140a Antigen; PDGF-R-Alpha; EC 2.7.10.1; PDGFR-2;
Gene ID
5156
UniProt ID
P16234
Cellular Localization
Membrane; Single-pass type II membrane protein
Involvement in Disease
Diseases associated with CD38 include Richter's Syndrome and Prolymphocytic Leukemia.
Related Pathways
Its related pathways are Calcium signaling pathway and Cell-type Dependent Selectivity of CCK2R Signaling.
Function
Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Field of research
Cancer antibody; Developmental Biology antibody; Immune System antibody; Metabolism antibody; Pro-B Cell Marker antibody; Pre-B Cell Marker antibody
Post-translational modifications
1. Glycosylation at Asn100, Asn164, Asn209, and Asn219 2. Modification sites at PhosphoSitePlus 3. Glycosylation from GlyConnect
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-017ZP
Description
Daratumumab is an anticancer drug that specifically targets CD38.
Antibody Indication
Multiple Myeloma (MM)
