Anti-Rat C5aR Monoclonal Antibody (clone R63) -0.5 mg (CAT#: CB-P314-AB) Datasheet

Antibody

The monoclonal antibody R63 reacts with the rat C5a receptor (CD88). Rat anaphylactoxin C5a is a 77-amino acid glycopeptide produced by the proteolysis of C5. It is one of the most effective chemical attractants for inflammation. It also interacts with two C5a receptors, C5aR and C5L2.-Most of the effects of C5a are mediated through C5aR. C5aR plays a key role in triggering acute inflammation. C5a receptors are seven transmembrane GTP binding protein couples Co-receptor belongs to the rhodopsin supergene family. The 45 kDa C5a receptor is expressed by white blood cells such as neutrophils, eosinophils, basophils, monocytes, dendritic cells and mast cells. C5aR can be expressed on immune cells and non-immune cells. The latter includes vascular endothelial cells, cardiomyocytes and bronchial cells. C5aR signaling involves intracellular calcium mobilization and activation of protein kinase B (PKB) and phospholipase D (PLD) pathways. The expression level of aR has been related to the pathogenesis of many inflammatory diseases, autoimmune and neurodegenerative diseases such as rheumatoid arthritis, multiple sclerosis, atherosclerosis and inflammatory bowel disease. The blockade of C5aR in the body is greatly reduced Inflammatory damage. Using immunohistology, there is no evidence that non-bone marrow expression in healthy control rats. However, in the case of inflammation, C5aR was found to be upregulated in various organs and tissues including the liver.
R63 points to Ex1, the amino terminal domain of rat C5aR.

Infectious diseases, Nephrology