Complement Classical Pathway ELISA [Human] (CAT#: CB-P064-K) Datasheet

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The complement system plays an important role in chronic, autoimmune and infectious diseases. There are three ways of complement activation, namely the classic way, the alternative way and the lectin way.

Impaired complement activity can lead to human susceptibility to repeated attacks or severe infections, and may lead to the development of autoimmune diseases. Improper complement activation can lead to chronic inflammation and tissue damage.

In vitro activation of the complement sequence leads to the consumption of complement components, which in turn leads to a decrease in their concentration. Therefore, the determination of complement protein or complement activity is used to indicate whether the complement system has been activated by immune and/or pathogenic mechanisms. When a complement activation disease or genetic defect is suspected, both functional and immunochemical complement measurements are used to evaluate the subject. The level of complement activity assessed by functional assays takes into account the rate of synthesis, degradation, and component consumption, and provides a measure of pathway integrity, as opposed to immunochemical methods that specifically measure the concentration of various complement components.

The classical complement pathway ELISA is an enzyme immunoassay for the qualitative and/or semi-quantitative determination of the functional classical complement pathway in human serum. The results should not be used for clinical diagnosis or patient management.

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