Anti-Rat C1q Polyclonal Antibody-10 mg (CAT#: CB-P548-K) Datasheet

Antibody

The polyclonal antibody recognizes rat C1q, which is a 459 kDa molecule composed of three independent polypeptide chains. C1q, C1r and C1s together form the C1 macromolecule, which is the first part of the classical complement pathway. The interaction between the immune complex and C1q induces conformational changes in the C1 complex, thereby activating the classical pathway. C1q acts as a recognition unit by binding to the heavy chain of IgG or IgM (Fcγ and Fc micro), provided that the immunoglobulin binds to its antigen. In addition, C1q can bind to apoptotic vesicles, in which it activates the classical complement pathway and mediates phagocytosis. In this way, C1q promotes the clearance of apoptotic cells and subsequent exposure of self-antigens, thereby preventing stimulation of the immune system. C1q is mainly produced by macrophages, but also by follicular dendritic cells, finger cells and cells of the mononuclear macrophage lineage. C1q deficiency has a profound impact on host defense and immune complex clearance. Lack of C1q may lead to impaired clearance rate of apoptotic cells, leading to autoimmunity. Hereditary C1q deficiency is also associated with the development of systemic lupus erythematosus (SLE).