Anti-Human C3aR Monoclonal Antibody (clone 17) -10 mg (CAT#: CB-P478-K) Datasheet

Antibody

The monoclonal antibody 17 reacts with the human C3a receptor. The monoclonal antibody 17 is also referred to as clone hC3aRZ8 in the literature.
In the process of complement activation, C3a receptor acts as the cell surface receptor of anaphylatoxin C3a. C3a is the C-terminal 77 amino acid cleavage product of C3's α chain, but it has no effect on C3a-desArg. All cellular responses to C3a are specifically mediated through interaction with membrane-bound C3a receptors (seven transmembrane GTP-binding protein-coupled receptors of the rhodopsin supergene family). 54 kDa C3a receptors are widely distributed in myeloid cells, surrounding tissues and central nervous system. The expression of C3aR has been confirmed on neutrophils, monocytes, eosinophils, astrocytes, neurons and glial cells, and increased under inflammatory conditions. Even after stimulation, C3aR expression was not detected on lymphocytes and tonsil B cells.