Anti-Mouse Complement component 4 (C4) Monoclonal Antibody (clone 16D2) -10 mg (CAT#: CB-P533-K) Datasheet

Antibody

The monoclonal antibody 16D2 recognizes mouse complement factor C4 (previously known as Gg protein), which is composed of α-, β- and γ chains. The classical pathway of complement and the activation pathway of mannose-binding lectin converge at C4. MASP- 1 and MASP-2 cleave C4 to form C4a and C4b. Subsequently, C4b can be cleaved into C4c and C4d by other serum enzymes. The monoclonal antibody 16D2 reacts with intact C4, C4b and C4d.
C4 is an acute phase protein produced by hepatocytes, monocytes and intestinal epithelial cells. It can be used as a marker for activating the classical complement pathway in experimental animals. Recent studies have shown that there is an association between transplant rejection and C4d deposition in a mouse model of heart transplantation.