Anti-Human Complement 3 glomerulopathy (C3g) Monoclonal Antibody (clone 9) -10 mg (CAT#: CB-P474-K) Datasheet

Antibody

Single colon antibody 9 (also known as YB2/90-5-20) reacts with neoantigens on iC3, iC3b, C3dg and C3g. However, C3g itself is a small fragment that may not be formed in the body. The complement system is an important factor in innate immunity. The third complement component, C3, is essential to the classical, alternative and lectin pathways of complement activation. The activation products of the complement cascade contain new epitopes that are not present in various natural components. The synthesis of C3 is tissue-specific and is regulated in response to a variety of stimulants. C3 is the most abundant protein in the complement system, and the serum protein level is about 1.3 mg/ml. Inherited C3 deficiency makes people prone to bacterial infections. C3 fragments are deposited in tissues at the site of antibody-mediated immunopathology. In ulcerative colitis and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. The proteolysis of C3 convertase cleaves C3 into C3a and C3b. C3b attaches to the immune complex and is further cleaved into iC3b and C3f. iC3b is further processed into C3c and C3dg. C3dg can be cleaved into C3d and C3g, although this does not occur in plasma. Monoclonal antibody 9 recognizes iC3b, C3dg and C3g in plasma. The monoclonal antibody does not recognize C3 or C3b.