Product Type
Antibody
Description
CD35 (CR1) is a type 1 membrane glycoprotein that participates in the clearance of immune complexes, regulates cell surface auto-complement activation and leukocyte-mediated complement-dependent cytotoxicity. CD35 inhibits complement activation through two different mechanisms. CD35 is a cofactor CD35 that mediates the decay and dissociation of C3 and C5 convertases. CD35 exists on red blood cells, neutrophils, monocytes and dendritic cells.
There are four variants of CD35 (CR1) with different molecular masses: 190 kDa (CR-1A), 220 kDa (CR1-B), 160 kDa (CR1-C) and 250 kDa (CR1-D).
The monoclonal antibody 31R binds to an epitope of CR1.
Disease
Autoimmunity, Infectious diseases
Size
100 µg
Species
Human
Clonality
Monoclonal
Clone Number
31R
Buffer
PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin.
Application
Flow cytometry, Frozen sections, Immuno assays, Immuno precipitation, Paraffin sections, Western blot
Application Notes
For immunohistology, the flow cytometer and Western blot diluent that will be used depend on the detection system used. It is recommended that users test reagents and determine their own optimal dilution. The typical initial working dilution is 1:10.
Storage Instructions
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Alternative Names
CR1; C3BR; C4BR; CD35; KN; complement component 3b/4b receptor 1 (Knops blood group); complement C3b/C4b receptor 1 (Knops blood group)
