Anti-Human CD46 Monoclonal Antibody (clone M177) -100 µg (CAT#: CB-P144-AB) Datasheet

Product Type
Antibody
Description
The monoclonal antibody M177 recognizes CD46, also known as membrane cofactor protein (MCP). CD46 is a 45-70 kDa protein with genetic and tissue-specific heterogeneity.-It is found in all cells except red blood cells and It is expressed in tissues. This function is achieved by inhibiting the function of coenzymes C3b and C4b. The serine protease I of plasma I allows this combination to degrade C3b and C4b and protect the host against auto-attack cells. It can also be used as The receptor for the measles virus.
The four isoforms of CD46 are dominant and are produced by alternative splicing of a single CD46 gene. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)). The monoclonal antibody M177 reacts with the SCR2 domain.
Disease
Infectious diseases, Tumor immunology
Size
100 µg
Immunogen
Purified MCP
Species
Human
Host
Mouse
Clonality
Monoclonal
Isotype
Mouse IgG1
Clone Number
M177
Buffer
PBS with a concentration of at least 0.5 mg/ml. The endotoxin concentration is < 24 EU/mg, determined with HIT302 LAL Assay.
Application
Flow cytometry, Frozen sections, Functional studies, Immuno assays, Immuno precipitation, Western blot
Application Notes
The diluent used depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution. The typical initial working dilution is 1:50. For functional studies, the in vitro dilution must be optimized in the user's experimental environment.
Storage Instructions
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Target
CD46
Alternative Names
Membrane cofactor protein; TLX; trophoblast leucocyte common antigen

All products and services are for Research Use Only. Do Not use in humans.

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