Product Type
Antibody
Description
The monoclonal antibody MM10 recognizes membrane cofactor protein (MCP), also known as CD46. MCP is a type I membrane glycoprotein consisting of four isoforms, namely two CD isoforms (51-58 kDa) and two BC isoforms (59-68 kDa), which are passed through a single CD46 Generated by alternative splicing of genes. Membrane cofactor protein is expressed in all cells and tissues except red blood cells. Membrane cofactor proteins are used to down-regulate complement activation on host tissues. MCP is a cofactor for factor 1 mediated cleavage of C3b and C4b. This method can protect host cells from autologous attack. MCP is a receptor for a variety of pathogens, including measles virus, streptococcus pyogenes and pathogenic Neisseria.
Disease
Autoimmunity, Nephrology
Size
100 µg
Immunogen
Mouse CD46-human Fc fusion protein
Species
Mouse
Cross reactivity
Rat
Clonality
Monoclonal
Clone Number
MM10
Buffer
PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
Application
Flow cytometry, Frozen sections, Immuno assays, Immuno fluorescence, Western blot
Application Notes
For immunohistology, flow cytometry and western blotting, the diluent to be used depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution. The typical initial working dilution is 1:50.
Storage Instructions
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Alternative Names
MCP; CD46; Trophoblast leukocyte common antigen; TLX; measles virus receptor
