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Anti-Lewis Y Recombinant Immunotoxin (BR96-RA) (CAT#: BioBet-IT146Z) Datasheet

Target
Lewis Y
IT Type
Antibody-based IT
Description
BR96 was conjugated to the ricin A chain toxin to form the immunotoxin, BR96-RA.
Indication
Ovarian Cancer; Small Cell Lung Cancer
Classification
Immuntoxin; biobetter
Construction
BR96-RA

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
Lewis Y
Full Name
Lewis Y
Alternative Names
Lewis Y;
Antibody Clone
BR96
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
scFv
Host
Mouse
Species Reactivity
Human
Antibody Indication
Ovarian Cancer; Small Cell Lung Cancer
Toxic Moiety
Ricin toxin A chain (RTA)
Organism
Ricinus communis (Castor bean)
Family
Ricin
Molecular Mass
30.1 kDa
Toxic MOA
Ricin toxin A chain (RTA) is an N-glycoside hydrolase composed of 267 amino acids. Ricin is a toxalbumin, a biological toxin whose mechanism of action is inhibition of protein synthesis (manufacture of proteins) in eukaryotic cells; cell death results from the absence of proteins.

The antibody portion mediated selective binding to target cells, while the toxin portion mediated translocation into the cytosol and subsequent cell killing.

Ovarian Cancer; Small Cell Lung Cancer

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All products and services are for Research Use Only. Do Not use in humans.

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