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Anti-Lewis Y Recombinant Immunotoxin LMB-7 (B3(scFv)-PE38) (CAT#: BioBet-IT132Z) Datasheet

Target
Lewis Y
IT Type
Antibody-based IT
Description
LMB-7 is a single-chain immunotoxin in which the monoclonal antibody B3 is coupled to NLysPE38 near its N terminus.
Indication
Ovarian Cancer; Small Cell Lung Cancer
Classification
Immuntoxin; biobetter
Construction
B3(scFv)-PE38

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
Lewis Y
Full Name
Lewis Y
Alternative Names
Lewis Y;
Antibody Clone
B3
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
scFv
Host
Mouse
Species Reactivity
Human
Antibody Indication
Ovarian Cancer; Small Cell Lung Cancer
Toxic Moiety
PE38
Organism
Pseudomonas aeruginosa exotoxin A
Family
Pseudomonas exotoxin A
Molecular Mass
38 kDa
Toxic MOA
PE38 is a 38 kDa truncated form of Pseudomonas exotoxin (PE) containing amino acids 253–364 and 381–613. Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. Vibrio cholerae produces a similar protein called Cholix toxin (Q5EK40). It inhibits elongation factor 2. This is achieved by ADP ribosylation of EF2 using NAD +. This then causes the extension of the polypeptide to stop. This mechanism is similar to diphtheria toxin.

The antibody portion mediated selective binding to target cells, while the toxin portion mediated translocation into the cytosol and subsequent cell killing.

Ovarian Cancer; Small Cell Lung Cancer

Related Products

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Anti-Lewis Y Recombinant Immunotoxin LMB-1 (B3(IgG)-PE38) (CAT#: BioBet-IT131Z)
Anti-Lewis Y Recombinant Immunotoxin (St6(dsFv)-PE38) (CAT#: BioBet-IT143Z)
Anti-Lewis Y Recombinant Immunotoxin (M1(Fv)-PE38) (CAT#: BioBet-IT139Z)
Anti-Lewis Y Recombinant Immunotoxin (M1(dsFv)-PE38) (CAT#: BioBet-IT140Z)
Anti-Lewis Y Recombinant Immunotoxin (B3(dsFv)-PE38) (CAT#: BioBet-IT144Z)
Anti-Lewis Y Recombinant Immunotoxin (Mt9(dsFv)-PE38) (CAT#: BioBet-IT145Z)
Anti-Lewis Y Recombinant Immunotoxin (B1(dsFv)PE33) (CAT#: BioBet-IT136Z)

All products and services are for Research Use Only. Do Not use in humans.

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