Book a Meeting

Anti-CD25 Recombinant Immunotoxin RFT5-dgA (RFT5(IgG)-dgA) (CAT#: BioBet-IT027Z) Datasheet

Target
CD25
IT Type
Antibody-based IT
Description
A recombinant immunotoxin, consisting of anti-CD25 monoclonal antibody RFT5 fused to deglycosylated ricin A chain (dgA), has potential anti-tumor activity. The monoclonal antibody portion of the RFT5-dgA immunotoxin is attached to CD25 (the α chain of the IL-2 receptor complex) on the cell membrane; after internalization, the dgA portion cleaves 4324 ribose and adenine bases in 28S ribosomal RNA The N-glycosidic bond between them leads to inactivation of ribosomes, inhibition of protein synthesis and cell death. CD25 is expressed on activated normal T cells and B cells and macrophages, and is frequently upregulated in many hematological malignancies.
Indication
Chronic Lymphocytic Leukemia
Classification
Immuntoxin; biobetter
Construction
RFT5(IgG)-dgA
Synonyms
anti-CD25 immunotoxin

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL2RA
Full Name
Interleukin-2 receptor alpha chain
Background
Interleukin-2 receptor alpha chain (also called CD25) is a protein that in humans is encoded by the IL2RA gene.
Alternative Names
IL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
Antibody Clone
RFT5
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
IgG
Host
Mouse
Species Reactivity
Human
Antibody Indication
Chronic Lymphocytic Leukemia
Toxic Moiety
Deglycosylated ricin A chain (dgA)
Organism
Ricinus communis (Castor bean)
Family
Ricin
Molecular Mass
30.1 kDa
Toxic MOA
Deglycosylated ricin A chain (dgA) is an N-glycoside hydrolase composed of 267 amino acids. Ricin is a toxalbumin, a biological toxin whose mechanism of action is inhibition of protein synthesis (manufacture of proteins) in eukaryotic cells; cell death results from the absence of proteins.

The monoclonal antibody portion of the RFT5-dgA immunotoxin is attached to CD25 (the α chain of the IL-2 receptor complex) on the cell membrane; after internalization, the dgA portion cleaves 4324 ribose and adenine bases in 28S ribosomal RNA The N-glycosidic bond between them leads to inactivation of ribosomes, inhibition of protein synthesis and cell death.

Chronic Lymphocytic Leukemia

Related Products

Anti-CD25 Recombinant Immunotoxin LMB-2 (Tac(Fv)-PE38) (CAT#: BioBet-IT026Z)
Anti-CD25 Recombinant Immunotoxin (Anti-Tac(Fv)-saporin) (CAT#: BioBet-IT028Z)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *
USA

UK

Germany

ISO 9001 Certified - Creative Biolabs Quality Management System.