BIOBETTER DATABASE

An archive of ADCC/CDC-enhanced biobetter antibodies developed by Creative Biolabs' state-of-the-art technology platform.

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Cell-Based Bioassay

Creative Biolabs has long-term experience in the detection of cell-based monoclonal antibody (mAb) therapeutics. Our scientific research team can provide support for the development, optimization, identification and verification of key bioassays, from simple first-level performance measurement to comprehensive characterization of biological activity of biobetter molecules. We have expertise in measuring the cell growth, cell death, induction of immune effector function, biomarker expression, induction or inhibition of signaling events, and methods for antibody internalization. Our experts work closely with you to provide a fully validated efficacy test to ensure a complete solution for your molecular characterization.

Cell-Based Assays We Deliver

The right partner is essential for the development and operation of cell-based potency and bioassays, as these are considered to be one of the most challenging methods required in the drug development process. In addition to playing a key role in potency determination, in vitro bioassays can also make true physiologically relevant measurements of the biological activity between the mAb, its intended target and Fc effector functions.

Creative Biolabs has spent time solving the well-known variability problem of cell-based bioassay and potency assays to provide a series of innovative technologies and bioassay methods. Our experienced team can provide key technical and regulatory guidance at all stages of biobetter drug development (from discovery to cGMP production) to provide effective and cost-effective total solutions.

Cell-Based Assays

Our broad range of cell-based bioassay platform methods ready to customize for your biobetter molecule include:

• Custom Potency Assays
• Antibody-Dependent Cell-mediated Cytotoxicity (ADCC) Assays
• Antibody-dependent Cellular Phagocytosis (ADCP) Assays
• Complement-Dependent Cytotoxicity (CDC) Assays
• Immune Cell Assays

From early candidate selection and product characterization to production, we provide a detection solution through the Mechanism of Action (MOA). Our testing method allows for flexible endpoints (e.g. Fluorescence, Luminescence and Fluorescence Resonance Energy Transfer (FRET)), allowing for a wider assessment of MOA, including:

• Cell Proliferation
• Neutralize
• Cytokine release
• Cell signal modulation
• Regulation of inflammatory response (immune cell function and supplement)
• Receptor activation
• Cell Death (apoptosis / necrosis)

• Receptor / ligand binding
• Receptor activation / internalization
• Cell migration & invasion
• Cell adhesion (static and flow dynamic assays)
• Biomarker Expression on protein (intracellular, secreted and surface marker analysis) and on mRNA level
• Immune cell activation and proliferation
• Cytokine quantification

Please browse the product list below to find the right product for you.

CAT# Product Name Assay Type Product Type Inquiry
CB-P225-K Anti-Human gC1q-R Monoclonal Antibody (clone 74.5.2) -100 µg Complement Assay Antibody
CB-P226-K Anti-Human gC1qR Monoclonal Antibody (clone 60.11), FITC, -100 µg Complement Assay Antibody
CB-P227-K Anti-Human gC1qR Monoclonal Antibody (clone 60.11) -100 µg Complement Assay Antibody
CB-P229-K Anti-Mouse C3aR Monoclonal Antibody (clone 14D4) -100 µg Complement Assay Antibody
CB-P346-K Anti-Human MASP-2/MAp19 Monoclonal Antibody (clone 6G12) -0.5 mg Complement Assay Antibody
CB-P351-K Anti-Human CD11b Monoclonal Antibody (clone Bear-1) -0.5 mg Complement Assay Antibody
CB-P377-K Anti-Human MBL Monoclonal Antibody (clone 3E7) -0.5 mg Complement Assay Antibody
CB-P382-K Anti-Mouse C3aR Monoclonal Antibody (clone 14D4) -0.5 mg Complement Assay Antibody
CB-P405-K Anti-Mouse MBL-A Monoclonal Antibody (clone 8G6) -0.5 mg Complement Assay Antibody
CB-P430-K Anti-Human CD46 Monoclonal Antibody (clone M177) -10 mg Complement Assay Antibody
CB-P450-K Anti-Human Complement factor I Monoclonal Antibody (clone 1C11) -10 mg Complement Assay Antibody
CB-P451-K Anti-Human Complement factor I Monoclonal Antibody (clone MBI-1) -10 mg Complement Assay Antibody
CB-P452-K Anti-Human C3c Monoclonal Antibody (clone F1-4) -10 mg Complement Assay Antibody
CB-P453-K Anti-Human CFHR1-2 Monoclonal Antibody (clone JHD-7.10.1) -10 mg Complement Assay Antibody
CB-P454-K Anti-Human MASP-1 Monoclonal Antibody (clone 4H2A9) -10 mg Complement Assay Antibody

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All products and services are for Research Use Only. Do Not use in humans.

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