Anti-Mouse C5aR Monoclonal Antibody (clone 10/92) -10 mg (CAT#: CB-P528-K) Datasheet

Antibody

The monoclonal antibody 10/92 recognizes the mouse receptor C5a (C5aR, CD88). Mouse anaphylactoxin C5a is a 74-residue glycopolypeptide, which is produced by proteolytic cleavage of complement factor C5 during complement activation. It can be proved that the various biological effects caused by C5a make it take granulocytes and macrophages as the main target cells and become important mediators of inflammation. All cellular responses to C5a are mediated through interaction with membrane-bound C5a receptors, which are seven transmembrane GTP-binding protein-coupled receptors of the rhodopsin supergene family. The 45 kDa C5a receptor is expressed by neutrophils, monocytes/macrophages, dendritic cells, astrocytes and microglia. In contrast, C5a receptors were not detected on resting or stimulated murine T and B lymphocytes. The monoclonal antibody 10/92 does not inhibit the binding of C5a to its receptor.