Description
Anti-Human CTLA-4-Fc silent antibody is derived from clone MDX-010, which is a Human monoclonal antibody targeting the CTLA-4. And it is intended for the research of Metastatic melanoma.
Research Area
Cell Biology, Immunology,
Antigen Distribution
CTLA4 is constitutively expressed in regulatory T cells.
Disease
Metastatic melanoma
Immunogen
Recombinant Human CTLA-4 protein
Application
Block, CyTOF®, ELISA, FC
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Handling Advice
This product is for research use only. It is not intended for use in therapeutic or diagnostic procedures for humans or animals.
Storage Instructions
Product should be stored at -80°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Official Name
Cytotoxic T-lymphocyte protein 4
Full Name
Cytotoxic T-lymphocyte protein 4
Background
Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a protein receptor that serves as an immune checkpoint and down-regulates the immune system. CTLA-4 is constitutively expressed in regulatory T cells but is only upregulated in conventional T cells following activation. Many cancers, including Melanoma, are associated with CTLA-4 upregulation because the body's ability to recognize and destroy cancer cells is hampered by an inhibitory mechanism.
Alternative Names
CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3
