Anti-Human CD46 Monoclonal Antibody (clone M177), FITC, -10 mg (CAT#: CB-P493-K) Datasheet

Antibody

The monoclonal antibody M177 recognizes CD46, also known as membrane cofactor protein (MCP). CD46 is a 45-70 kDa protein with genetic and tissue-specific heterogeneity. -It is expressed in all cells and tissues except red blood cells. CD46 is used to inhibit complement activation on host tissues. It performs this function by acting as a cofactor that binds to C3b and C4b. Plasma serine protease factor I allows this combination to degrade C3b and C4b, and protects the host cell from autologous attack. It can also act as a receptor for measles virus. The four isoforms of CD46 are dominant and are produced by alternative splicing of a single CD46 gene. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)). The monoclonal antibody M177 reacts with the SCR2 domain.