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Anti-Human CD46 Monoclonal Antibody (clone M177), FITC, -10 mg (CAT#: CB-P493-K) Datasheet

Product Type
The monoclonal antibody M177 recognizes CD46, also known as membrane cofactor protein (MCP). CD46 is a 45-70 kDa protein with genetic and tissue-specific heterogeneity. -It is expressed in all cells and tissues except red blood cells. CD46 is used to inhibit complement activation on host tissues. It performs this function by acting as a cofactor that binds to C3b and C4b. Plasma serine protease factor I allows this combination to degrade C3b and C4b, and protects the host cell from autologous attack. It can also act as a receptor for measles virus. The four isoforms of CD46 are dominant and are produced by alternative splicing of a single CD46 gene. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)). The monoclonal antibody M177 reacts with the SCR2 domain.
100 µg

All products and services are for Research Use Only. Do Not use in humans.


Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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