Anti-Human C1s Monoclonal Antibody (clone M81) -10 mg (CAT#: CB-P489-K) Datasheet

Antibody

The monoclonal antibody M81 reacts with an epitope on C1 (a subcomponent of the first component of C (C1)) activated by human protein C. Activated C1s is a glycosylated single-peptide zymogen with a molecular weight of 85 kD. The activation of the protease C1s occurs through the cleavage of the active form of C1r. The activated protease (activated C1s) is composed of H and L chains connected by disulfide bonds. Activated C1s is a serine protease whose catalytic site is located in the L chain. The activation of the classical C pathway is triggered by activated C1s that cleave C4 and C2 to form the C3 convertase C4bC2a. The epitope recognized by antibody M81 is the IV and/or V domain of the activated C1sγ domain. The monoclonal antibody M81 prevents the activation of C4 and the binding of C4 to activated C1s. The antibody reacts near the binding site of C1s and reacts with active and inactive C1s.