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Anti-Human Complement factor B/Ba Monoclonal Antibody (clone P21/15) -0.5 mg (CAT#: CB-P334-AB) Datasheet

Product Type
The monoclonal antibody P21/15 recognizes human complement factor B/Ba. Factor B is an acute phase protein. The level of factor B rises during inflammation. Complement factor B is a single chain molecule of 764 amino acids (MW 90 kD), including a leader peptide of 25 amino acids. Factor B provides the catalytic subunit of the C3/C5 convertase that replaces the complement pathway. The assembly of C3 convertase (C3bBb) requires the combination of factor B and C3b (C3.H2O), and factor D-mediated cleavage of the binding factor B leads to the release of Ba (MW 33 kD). C3 convertase is stabilized by the binding of properdin. This provides a positive amplification loop for the classical and alternative complement pathways. Bb (MW 60 kD) is the serine protease element of the invertase. After cutting C3, C5 convertase ((C3b)2Bb) is formed. The Bb fragment may be regarded as a better indicator of the complement activation pathway than Ba, because impaired renal filtration does directly affect Ba levels. Compared with normal people, Bb in patients with chronic renal failure (CRF) increased by 2.2 times, while the plasma concentration of Ba in CRF was 8.4 times higher, and the plasma concentration of Ba in patients with end-stage renal disease (ESRD) was 16 times higher. In addition to complement activation, factor B fragments also participate in other immune functions.
Infectious diseases, Nephrology
100 µg
Mouse IgG2a
Clone Number
PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
Immuno assays, Immuno precipitation, Western blot
Application Notes
For Western blotting, the diluent that will be used depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution. The typical initial working dilution is 1:50.
Storage Instructions
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Complement factor B/Ba
Alternative Names
CFB; Cfb; AI195813; AI255840; Bf; C2; Fb; H2-Bf; AHUS4; ARMD14; BFD; CFAB; CFBD; FBI12; GBG; PBF2; complement factor B

All products and services are for Research Use Only. Do Not use in humans.


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