Anti-CD4 Antibody, ADCC Enchanced (BioBet-CB-080LX) (CAT#: BioBet-CB-080LX) Datasheet

CD4

CD4 molecule

This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020]

CD4 molecule; CD4

Cell Biology, Immunology,

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1

BioBet-CB-080LX

Humanized

Human

ADCC-Enhanced Anti-Human CD4 (UB-421) Antibody is derived from clone UB-421, which is a Humanized monoclonal antibody with enhanced ADCC activity. Antibody-dependent cellular cytotoxicity (ADCC) is an important function of antibody. It is a part of the humoral immune response to limit and contain infection. The antibody targets the CD4, and it is intended for the research of HIV infections .

HIV infections

HIV infections