Anti-CD4 Antibody, Non-Fucosylated (BioBet-144ZP) (CAT#: BioBet-144ZP) Datasheet

CD4

CD4 Molecule

CD4 (CD4 Molecule) is a Protein Coding gene.
Diseases associated with CD4 include Okt4 Epitope Deficiency and Pilonidal Sinus.
Among its related pathways are G-protein signaling N-RAS regulation pathway and PEDF Induced Signaling.
Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding.

Zanolimumab; humax-cd4; 652153-01-0; 6G5.2; HuMax-CD4; CD4; CD4 molecule; CD4 antigen (p55), T cell surface glycoprotein CD4; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD4mut;

Plasma membrane

Diseases associated with CD4 include Okt4 Epitope Deficiency and Human Immunodeficiency Virus Infectious Disease.

Its related pathways are Clathrin-mediated endocytosis and TCR Signaling (Qiagen).

Integral membrane glycoproteins play an important role in the immune response and perform multiple functions in fighting external and internal attacks. In T cells, it is mainly used as a co-receptor for MHC class II molecules: peptide complexes. Class II peptide antigens are derived from extracellular proteins, while class I peptides are derived from cytoplasmic proteins. It also interacts with MHC II presented by T cell receptors (TCR) and antigen presenting cells (APCs). Then, the Src kinase LCK was called to the vicinity of the TCR-CD3 complex. Then, LCK activates different intracellular signaling pathways through phosphorylation of various substrates, which ultimately leads to the production, activity, adhesion, and activation of T helper cells. In other cells such as macrophages or NK cells, they participate in differentiation/activation, cytokine expression and cell migration through a TCR/lck-independent pathway. Participate in the development of thymic t helper cells, triggering monocytes to differentiate into functional mature macrophages. 2.

Developmental Biology antibody; Immune System antibody; Regulatory T cells Study antibody; T-cell infiltration Study antibody; Tumor-infiltrating Lymphocyte Study antibody

Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG4, λ

Clenoliximab

Chimeric

Human

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant (primate/human) antibody expressed in CHO binding to human CD4/p55. Clenoliximab is a monoclonal antibody against CD4. It acts as an immunomodulator and has been investigated for the treatment of rheumatoid arthritis. The drug is a antibody from Macaca irus and Homo sapiens.

Cutaneous T cell lymphoma (CTCL)

Cutaneous T cell lymphoma (CTCL)