Anti-CD4 Antibody, Non-Fucosylated (BioBet-667ZP) (CAT#: BioBet-667ZP) Datasheet

CD4

CD4 molecule

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

CD4; CD4 molecule; CD4mut; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3

Plasma membrane

Diseases associated with CD4 include Okt4 Epitope Deficiency and Human Immunodeficiency Virus Infectious Disease.

Its related pathways are Clathrin-mediated endocytosis and TCR Signaling (Qiagen).

Integral membrane glycoproteins play an important role in the immune response and perform multiple functions in fighting external and internal attacks. In T cells, it is mainly used as a co-receptor for MHC class II molecules: peptide complexes. Class II peptide antigens are derived from extracellular proteins, while class I peptides are derived from cytoplasmic proteins. It also interacts with MHC II presented by T cell receptors (TCR) and antigen presenting cells (APCs). Then, the Src kinase LCK was called to the vicinity of the TCR-CD3 complex. Then, LCK activates different intracellular signaling pathways through phosphorylation of various substrates, which ultimately leads to the production, activity, adhesion, and activation of T helper cells. In other cells such as macrophages or NK cells, they participate in differentiation/activation, cytokine expression and cell migration through a TCR/lck-independent pathway. Participate in the development of thymic t helper cells, triggering monocytes to differentiate into functional mature macrophages.

Developmental Biology antibody; Immune System antibody; Regulatory T cells Study antibody; T-cell infiltration Study antibody; Tumor-infiltrating Lymphocyte Study antibody

Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

M-T413

Chimeric

Human

This is an anti-CD4 monoclonal antibody (mAbs) that have shown considerable promise in the treatment of rheumatoid arthritis, psoriasis, and allograft rejection and may have potential use in blocking HIV-1 infection.

Autoimmune Diseases; HIV Infection

Autoimmune Diseases; HIV Infection