Background
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene.
Alternative Names
UPK1B; uroplakin 1B; UPIB; UPK1; TSPAN20; uroplakin-1b; UP1b; tspan-20; tetraspan; uroplakin Ib; tetraspanin-20
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with UPK1B include Transitional Cell Carcinoma and Fraser Syndrome 1.
Function
The composition of the asymmetric unit membrane (AUM); a highly specialized biomembrane crafted from terminally differentiated urothelial cells. It may play an important role in normal bladder epithelial physiology, and may regulate the membrane permeability of superficial umbrella cells or stabilize the apical membrane (similar) through the AUM/cytoskeleton interaction.
Post-translational modifications
1.N-glycosylated with high-mannose oligosaccharides 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Description
The antibody that specifically recognize and bind to UPK-Ib are useful in the diagnisic and/or treatment of cancer associated with abnormal expression of UPK-Ib. The disease state includes, but is not limited to, bladder cancer, transitional cell carcinoma of the bladder, ovarian cancer, Brenner ovarian cancer, lung cancer, and the like.
