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Non-fucosylated Anti-Human Sclerostin (Romosozumab) Therapeutic Antibody (CAT#: BioBet-012ZP) Datasheet

ADCC-enhanced Romosozumab is a non-fucosylated anti-Sclerostin therapeutic biobetter antibody.
Severe Eosinophilic Asthma
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Sclerostin antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
Full Name
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Alternative Names
SOST; sclerostin; CDD; VBCH; SOST1
Gene ID
UniProt ID
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with SOST include Sclerosteosis 1 and Craniodiaphyseal Dysplasia, Autosomal Dominant.
Related Pathways
Its related pathways are Signaling by GPCR and Signaling by Wnt.
Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Post-translational modifications
Glycosylation at Asn53 and Asn175
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
Antibody Clone
Species Reactivity
Romosozumab is a humanized monoclonal antibody that targets sclerostin. It is used in postmenopausal women with a high risk of fracture and in patients who have failed treatment or are intolerant to other osteoporosis treatments. Osteoporosis in the treatment of osteoporosis. Studies have shown that the drug can increase bone formation and reduce bone resorption in postmenopausal women with low bone density. Romolimumab is approved for medical use in the United States in 2019. Romosozumab is sold in the United States by Amgen under the trade name Evinity.
Not Available

Osteoblasts secrete sclerostin, which promotes bone resorption through two mechanisms: a. Inhibition of bone formation by binding to low-density lipoprotein (LDL) receptor-related proteins 5 and 6 of osteoblasts, thereby inhibiting the Wnt signaling pathway; b Increase the production of nuclear factor kappa-ligand (RANKL) 2 receptor activators to promote bone resorption.
Romosozumab targets and inhibits sclerostin, and on the one hand prevents the inhibition of bone formation by allowing Wnt to bind to LDL receptor-related proteins. Activation of the Wnt pathway leads to promotion of osteoblast survival and proliferation; on the other hand, the inhibitory effect of Romosozumab on sclerostin also inhibits RANKL-dependent osteoclast activity and bone resorption.
Autoimmune diseases

All products and services are for Research Use Only. Do Not use in humans.


Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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