Non-Fucosylated Anti-Human Notch2 (huMAb4D5-8 ) Therapeutic Antibody (CAT#: BioBet-1476ZP) Datasheet

NOTCH2

notch 2

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

NOTCH2; notch 2; hN2; AGS2; HJCYS; neurogenic locus notch homolog protein 2; Notch homolog 2;

Plasma membrane, Nucleus

Diseases associated with NOTCH2 include Alagille Syndrome 2 and Hajdu-Cheney Syndrome.

Its related pathways are Neuroscience and Signaling by GPCR.

As a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1), it regulates cell fate decisions. The released notch intracellular domain (NICD) activates the ligand, forms a transcription activator complex with RBPJ/RBPSUH, and activates the gene of the split site enhancer. Affect the implementation of differentiation, proliferation and apoptosis programs (through similarity). Participate in bone remodeling and homeostasis. Cooperate with RELA/p65 to enhance the activity of NFATc1 promoter and positively regulate the osteoclast differentiation induced by rankl. Positively regulate the self-renewal of liver cancer cells.

Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity). Hydroxylated by HIF1AN. Can be either O-glucosylated or O-xylosylated at Ser-613 by POGLUT1.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

huMAb4D5-8

Human

Human

This is anti-Notch antibody, and in particular, antibody that bind Notch2 NRR and is used for B-cell neoplasms.

B-cell Neoplasms

B-cell Neoplasms