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Non-fucosylated Anti-Human CSF1R (Cabiralizumab) Therapeutic Antibody (CAT#: BioBet-174ZP) Datasheet

Target
CSF1R
Isotype
IgG4, κ
Description
ADCC-enhanced Cabiralizumab is a non-fucosylated anti-CSF1R therapeutic biobetter antibody.
Indication
Rheumatoid arthritis (RA), Pigmented villonodular synovitis (PVNS)
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CSF1R antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CSF1R
Full Name
Colony Stimulating Factor 1 Receptor
Alternative Names
Colony stimulating factor 1 receptor; CSF-1R; CSF-1-R; macrophage colony-stimulating factor 1 receptor; c-fms; FMS; CD115
Gene ID
1436
UniProt ID
P07333
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with CSF1R include Leukoencephalopathy, Hereditary Diffuse, With Spheroids and Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis.
Related Pathways
Its related pathways are Transcriptional misregulation in cancer and Activation of cAMP-Dependent PKA.
Field of research
Cell Biology and Cellular Response antibody; Immune System antibody; Signaling Transduction antibody
Post-translational modifications
Autophosphorylated in response to CSF1 or IL34 binding. Phosphorylation at Tyr-561 is important for normal down-regulation of signaling by ubiquitination, internalization and degradation. Phosphorylation at Tyr-561 and Tyr-809 is important for interaction with SRC family members, including FYN, YES1 and SRC, and for subsequent activation of these protein kinases. Phosphorylation at Tyr-699 and Tyr-923 is important for interaction with GRB2. Phosphorylation at Tyr-723 is important for interaction with PIK3R1. Phosphorylation at Tyr-708 is important for normal receptor degradation. Phosphorylation at Tyr-723 and Tyr-809 is important for interaction with PLCG2. Phosphorylation at Tyr-969 is important for interaction with CBL. Dephosphorylation by PTPN2 negatively regulates downstream signaling and macrophage differentiation. Ubiquitinated. Becomes rapidly polyubiquitinated after autophosphorylation, leading to its degradation.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG4, κ
Antibody Clone
Cabiralizumab
Host
Humanized
Species Reactivity
Human
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CSF1R. Cabiralizumab is a human monoclonal antibody that can be potentially used in the treatment of Rheumatoid arthritis (RA), Pigmented villonodular synovitis (PVNS).
Indication
Rheumatoid arthritis (RA), Pigmented villonodular synovitis (PVNS)

Rheumatoid arthritis (RA), Pigmented villonodular synovitis (PVNS)

Related Products

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Highly Galactosylated Anti-CSF1R (Emactuzumab) Antibody (CAT#: BioBet-GA-175ZP)
BetterBet™ Anti-CSF1R FcγRIIB Binding Enhanced Antibody (CAT#: AES-0622-ZP385)
Non-fucosylated Anti-Human CSF1R (Emactuzumab) Therapeutic Antibody (CAT#: BioBet-175ZP)
BetterBet™ Anti-CSF1R On-Target Antibody (CAT#: AES-0622-ZP713)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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