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Highly Galactosylated Anti-CSF1R (Emactuzumab) Antibody (CAT#: BioBet-GA-175ZP) Datasheet

Target
CSF1R
Isotype
IgG1, κ
Description
The Highly Galactosylated Anti-CSF1R (Emactuzumab), a biobetter antibody contains with a high level of galactosylation.
Indication
Rheumatoid arthritis (RA), Pigmented villonodular synovitis (PVNS)
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CSF1R antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CSF1R
Full Name
Colony Stimulating Factor 1 Receptor
Alternative Names
Colony stimulating factor 1 receptor; CSF-1R; CSF-1-R; macrophage colony-stimulating factor 1 receptor; c-fms; FMS; CD115
Gene ID
UniProt ID
Cellular Localization
Plasma membrane
Genecards
Involvement in Disease
Its related pathways are Transcriptional misregulation in cancer and Activation of cAMP-Dependent PKA.
Related Pathways
1.Tyrosine protein kinases, as cell surface receptors of CSF1 and IL34, play an important role in the regulation of the survival, proliferation and differentiation of hematopoietic precursor cells, especially monocytes, such as macrophages and monocytes. Promote the release of pro-inflammatory chemokines in response to IL34 and CSF1, thus playing an important role in the process of innate immunity and inflammation. It plays an important role in regulating the proliferation and differentiation of osteoclasts and regulating bone resorption, and is necessary for normal bone and tooth development. This is necessary for the normal fertility of men and women, and the normal development of mammary ducts and acinar structures during pregnancy. Promote the reorganization of the actin cytoskeleton, regulate the formation of membrane folds, cell adhesion and cell migration, and promote the invasion of cancer cells. Activate a variety of signaling pathways in response to ligand binding, including ERK1/2 and JNK pathways (PubMed:20504948, PubMed:30982609). 2.Phosphorylate PIK3R1, PLCG2, GRB2, SLA2 and CBL. The activation of PLCG2 leads to the production of cell signaling molecules triglycerides and inositol 1,4,5-triphosphate, and then leads to the activation of protein kinase C family members, especially PRKCD. The phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. The activated CSF1R also mediates the activation of MAPK1/ERK2 and/or MAPK3/ERK1 and the SRC family kinases SRC, FYN and YES1. The activated CSF1R transmits signals through proteins or adaptor proteins (such as GRB2) that directly interact with phosphorylated tyrosine residues in the cell. Promote the activation of STAT family members STAT3, STAT5A and/or STAT5B. Promote SHC1 and INPP5D/SHIP-1 tyrosine phosphorylation. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, which dephosphorylate the receptor and its downstream effectors and down-regulate through the rapid internalization of the activated receptor. In the central nervous system, it may be involved in the development of microglia macrophages (PubMed: 30982608).
Function
Cell Biology and Cellular Response antibody; Immune System antibody; Signaling Transduction antibody
Field of research
Autophosphorylated in response to CSF1 or IL34 binding. Phosphorylation at Tyr-561 is important for normal down-regulation of signaling by ubiquitination, internalization and degradation. Phosphorylation at Tyr-561 and Tyr-809 is important for interaction with SRC family members, including FYN, YES1 and SRC, and for subsequent activation of these protein kinases. Phosphorylation at Tyr-699 and Tyr-923 is important for interaction with GRB2. Phosphorylation at Tyr-723 is important for interaction with PIK3R1. Phosphorylation at Tyr-708 is important for normal receptor degradation. Phosphorylation at Tyr-723 and Tyr-809 is important for interaction with PLCG2. Phosphorylation at Tyr-969 is important for interaction with CBL. Dephosphorylation by PTPN2 negatively regulates downstream signaling and macrophage differentiation. Ubiquitinated. Becomes rapidly polyubiquitinated after autophosphorylation, leading to its degradation.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1, κ
Antibody Clone
Emactuzumab
Host
Humanized
Species Reactivity
Human
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Humanized antibody to Human CSF1R.
Indication
Rheumatoid arthritis (RA), Pigmented villonodular synovitis (PVNS)

Rheumatoid arthritis (RA), Pigmented villonodular synovitis (PVNS)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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