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Non-Fucosylated Anti-Human CCR4 (AT008) Therapeutic Antibody (CAT#: BioBet-634ZP) Datasheet

Target
CCR4
Isotype
IgG
Description
ADCC-Enhanced anti-CCR4 (AT008) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CCR4 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CCR4
Full Name
chemokine (C-C motif) receptor 4
Background
The protein encoded by this gene belongs to the G-protein-coupled receptor family. It is a receptor for the CC chemokine- MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.
Alternative Names
CCR4; chemokine (C-C motif) receptor 4; CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099; C-C chemokine receptor type 4; CCR-4; C-C CKR-4; chemokine (C-C) receptor 4
Gene ID
1233
Cellular Localization
Nucleus
Involvement in Disease
Diseases associated with CCR4 include Mycosis Fungoides and Peripheral T-Cell Lymphoma.
Related Pathways
Its related pathways are Signaling by GPCR and Akt Signaling.
Function
C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF subtype 1/CKLF1 high affinity receptors. The activity of this receptor is mediated by G(i) protein, which activates the phosphatidylinositol-calcium second messenger system. It can be used as a chemotactic homing receptor on circulating memory lymphocytes and as a co-receptor for HIV-2 isolates. In the central nervous system, it can mediate the survival of hippocampal neurons.
Post-translational modifications
In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
AT008
Host
Human
Species Reactivity
Human
Description
AT008 is a GPCR antibody program for chemokine receptor CCR4 as a potential treatment targeted against certain haematological and solid cancers.
Antibody Indication
Cancer

Cancer

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All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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