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Anti-CCR4 Antibody, Highly Galactosylated (CAT#: BioBet-GA-051ZP) Datasheet

Target
CCR4
Isotype
IgG1
Description
Anti-CCR4 Antibody, Highly Galactosylated (BioBet-GA-051ZP) is a humanized IgG1 antibody against CCR4 which contains with a high level of galactosylation.
Antibody Indication
Mycosis fungoides or Sézary syndrome
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CCR4 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CCR4
Full Name
C-C Motif Chemokine Receptor 4
Background
CCR4 (CC Motif Chemokine Receptor 4) is a Protein Coding gene.
Diseases associated with CCR4 include Cutaneous T Cell Lymphoma and Mycosis Fungoides.
Among its related pathways are Akt Signaling and Peptide ligandbinding receptors.
Gene Ontology (GO) annotations related to this gene include Gprotein coupled receptor activity and CC chemokine receptor activity.
An important paralog of this gene is CCR5.
Alternative Names
C-C Motif Chemokine Receptor 4, Chemokine (C-C Motif) Receptor 4, C-C CKR-4, CC-CKR-4, CMKBR4, CCR-4, K5-5, C-C Chemokine Receptor Type 4,
Gene ID
1233
Cellular Localization
Plasma membrane
Genecards
1605
Involvement in Disease
Its related pathways are Signaling by GPCR and Akt Signaling.
Related Pathways
C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF subtype 1/CKLF1 high affinity receptors. The activity of this receptor is mediated by G(i) protein, which activates the phosphatidylinositol-calcium second messenger system. It can be used as a chemotactic homing receptor on circulating memory lymphocytes and as a co-receptor for HIV-2 isolates. In the central nervous system, it can mediate the survival of hippocampal neurons.
Field of research
In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
BioBet-GA-051ZP
Host
Humanized
Species Reactivity
Human
Description
Mogamulizumab is a humanized, fucosylated monoclonal antibody against CC chemokine receptor 4 (CCR4). This product was used for the treatment of relapsed or refractory fungal fungal disease (MF) and Seth syndrome (SS).
Antibody Indication
Relapsed or refractory mycosis fungoides (MF) or Sézary syndrome (SS)

Relapsed or refractory mycosis fungoides (MF) or Sézary syndrome (SS)

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Anti-CCR4 Antibody, Recycling (CAT#: AES-0622-ZP177)
Non-Fucosylated Anti-Human CCR4 (Mogamuizumab) Therapeutic Antibody (CAT#: BioBet-1814ZP)
Anti-CCR4 Antibody, Non-Fucosylated (CAT#: BioBet-051ZP)
Non-Fucosylated Anti-Human CCR4 (Mogamulizumab/) Therapeutic Antibody (CAT#: BioBet-1815ZP)
Non-Fucosylated Anti-Human CCR4 (AT008) Therapeutic Antibody (CAT#: BioBet-634ZP)
Non-Fucosylated Anti-Human CCR4 (KM2760-1) Therapeutic Antibody (CAT#: BioBet-1681ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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