Description
CDC-enhanced Ofatumumab is a Fc-modified anti-CD20 therapeutic biobetter. Creative Biolabs' advanced CDC-enhanced antibody platform allows for the production of Fc engineered therapeutic CDC⁺ antibodies. By mutating key amino acids of the Fc region of Ofatumumab, the Fc region of Ofatumumab exhibits a greater binding capacity to C1q, thereby achieving enhanced CDC activity.
Indication
Chronic lymphocytic leukaemia
Phase IIIB-cell lymphoma
Diffuse large B cell lymphoma
Follicular lymphoma
Multiple sclerosis
Phase II Marginal zone B-cell lymphoma
Precursor cell lymphoblastic leukaemia-lymphoma
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop CDC-enhanced Ofatumumab. For commercial partners interested in our CDC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MS4A1
Full Name
membrane spanning 4-domains A1
Background
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.
Gene ID
931
UniProt ID
P11836
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
Human IgG1
Indication
Chronic lymphocytic leukaemia
Phase IIIB-cell lymphoma
Diffuse large B cell lymphoma
Follicular lymphoma
Multiple sclerosis
Phase II Marginal zone B-cell lymphoma
Precursor cell lymphoblastic leukaemia-lymphoma
Blood cancers
Chronic Lymphocytic Leukaemia (CLL)
Chronic Lymphocytic Leukemia (CLL) - Refractory
Autoimmune diseases
Rheumatoid Arthritis
Solide Tumors
Multiple Sclerosis
