IT Type
Antibody-based IT
Description
The recombinant immunotoxin is comprised of an anti-Pan T-cell immunoglobulin, coupled to a cytotoxic agent, A chain of ricin.
Indication
Cancer
Classification
Immuntoxin; biobetter
Construction
XMMLY-H65-RTA
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD5
Full Name
CD5 Molecule
Background
CD5 (CD5 Molecule) is a Protein Coding gene.
Diseases associated with CD5 include Thymus Cancer and Richter's Syndrome.
Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and B Cell Development Pathways.
Gene Ontology (GO) annotations related to this gene include receptor activity and scavenger receptor activity.
Gene ID
Entrez Gene: 921
UniProt ID
UniProtKB: P06127
Antibody Clone
XMMLY-H65
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
scFv
Antibody Indication
Cancer
Toxic Moiety
Ricin toxin A chain (RTA)
Organism
Ricinus communis (Castor bean)
Family
Ricin
Molecular Mass
30.1 kDa
Toxic MOA
Ricin toxin A chain (RTA) is an N-glycoside hydrolase composed of 267 amino acids. Ricin is a toxalbumin, a biological toxin whose mechanism of action is inhibition of protein synthesis (manufacture of proteins) in eukaryotic cells; cell death results from the absence of proteins.
The antibody portion mediated selective binding to target cells, while the toxin portion mediated translocation into the cytosol and subsequent cell killing.
