IT Type
Antibody-based IT
Description
The recombinant immunotoxin consists of an anti-CD5 monoclonal antibody that in combination with a diphtheria toxin. The toxin moiety retains its toxic function, and shows membrane translocation function to the cytosol in full amounts. The immunotoxin relates to a method of treating T cell leukemias and lymphomas, graft-versus-host diseases, and autoimmune diseases.
Indication
Cancer
Classification
Immuntoxin; biobetter
Construction
CD5(T101)-DT
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD5
Full Name
CD5 Molecule
Background
CD5 (CD5 Molecule) is a Protein Coding gene.
Diseases associated with CD5 include Thymus Cancer and Richter's Syndrome.
Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and B Cell Development Pathways.
Gene Ontology (GO) annotations related to this gene include receptor activity and scavenger receptor activity.
Alternative Names
CD5 Molecule; Lymphocyte Antigen T1/Leu-1; CD5 Antigen (P56-62); LEU1; T-Cell Surface Glycoprotein CD5; CD5 Antigen; T1;
Gene ID
Entrez Gene: 921
UniProt ID
UniProtKB: P06127
Antibody Clone
T101
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
scFv
Antibody Indication
Cancer
Toxic Moiety
DT
Organism
Corynebacterium
Family
Diphtheria toxin
Toxic MOA
Diphtheria toxin kills cells by inhibiting eukaryotic protein synthesis, and its mechanism of action has been extensively characterized. This potent toxin inactivates elongation factor (EF-2) required for protein synthesis. Specifically, diphtheria toxin transfers the ADP-ribose moiety of NAD to EF-2, and thus blocks the translational machinery of target cells.
The antibody portion mediated selective binding to target cells, while the toxin portion mediated translocation into the cytosol and subsequent cell killing.
