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Anti-CD30 Recombinant Immunotoxin (T25(dsFv)-PE38) (CAT#: BioBet-IT046Z) Datasheet

Target
CD30
IT Type
Antibody-based IT
Description
The recombinant anti-CD30 immunotoxin comprises a disulfide-linked Fv (VH/VL) anti-CD30 antibody fragment recombinantly connected to a 38 kD cytotoxic truncation of Pseudomonas exotoxin A ("PE", the 38 kD truncation is known in the art as "PE38"). PE38 is created by deleting from the 613 amino acid residue sequence of native PE residues 1-252, which correspond to domain I, along with residues 365-380 of domain Ib.
Indication
Hodgkin lymphoma
Classification
Immuntoxin; biobetter
Construction
T25(dsFv)-PE38

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TNFRSF8
Full Name
TNFRSF8
Background
CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker.
Alternative Names
TNFRSF8, CD30, D1S166E, Ki-1, tumor necrosis factor receptor superfamily member 8, TNF receptor superfamily member 8
Antibody Clone
T25
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
scFv
Host
Mouse
Species Reactivity
Human
Antibody Indication
Hodgkin lymphoma
Toxic Moiety
PE38
Organism
Pseudomonas aeruginosa
Family
Pseudomonas exotoxin A
Molecular Mass
38 kDa
Toxic MOA
PE38 is a 38 kDa truncated form of Pseudomonas exotoxin (PE) containing amino acids 253–364 and 381–613. Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. Vibrio cholerae produces a similar protein called Cholix toxin (Q5EK40). It inhibits elongation factor 2. This is achieved by ADP ribosylation of EF2 using NAD +. This then causes the extension of the polypeptide to stop. This mechanism is similar to diphtheria toxin.

The antibody portion mediated selective binding to target cells, while the toxin portion mediated translocation into the cytosol and subsequent cell killing.

Hodgkin lymphoma

Related Products

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Anti-CD30 Recombinant Immunotoxin (CL2(scFv)-PE38) (CAT#: BioBet-IT043Z)
Anti-CD30 Recombinant Immunotoxin (T6(dsFv)-PE38) (CAT#: BioBet-IT044Z)
Anti-CD30 Recombinant Immunotoxin (T24(dsFv)-PE38) (CAT#: BioBet-IT045Z)
Anti-CD30 Recombinant Immunotoxin (T14-A(dsFv)-PE38) (CAT#: BioBet-IT042Z)
Anti-CD30 Recombinant Immunotoxin (Ber-H2.dgA) (CAT#: BioBet-IT048Z)
Anti-CD30 Recombinant Immunotoxin (HRS-3.dgA) (CAT#: BioBet-IT047Z)

All products and services are for Research Use Only. Do Not use in humans.

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