IT Type
Antibody-based IT
Description
An immunotoxin, comprising a mutant diphtheria toxin moiety linked to a targeting moiety- a fold-back diabody specific for a cell surface antigen CD3.
Indication
Head and neck cancer, melanoma, and renal cell, ovarian, and colorectal carcinoma
Classification
Immuntoxin; biobetter
Construction
DT390scfbDb(UCHT1)
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD3
Full Name
cluster of differentiation 3
Background
CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells).
Alternative Names
CD3
Antibody Clone
UCHT1
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
Diabody
Antibody Indication
Head and neck cancer, melanoma, and renal cell, ovarian, and colorectal carcinoma
Toxic Moiety
DT390
Organism
Corynebacterium
Family
Diphtheria toxin
Toxic MOA
Diphtheria toxin kills cells by inhibiting eukaryotic protein synthesis, and its mechanism of action has been extensively characterized. This potent toxin inactivates elongation factor (EF-2) required for protein synthesis. Specifically, diphtheria toxin transfers the ADP-ribose moiety of NAD to EF-2, and thus blocks the translational machinery of target cells.
The antibody portion mediated selective binding to target cells, while the toxin portion mediated translocation into the cytosol and subsequent cell killing.
Head and neck cancer, melanoma, and renal cell, ovarian, and colorectal carcinoma
