IT Type
Antibody-based IT
Description
A recombinant immunotoxin, which is composed of the Fv part of anti-CD22 antibody RFB4 and the fragment of Pseudomonas exotoxin A with potential antitumor activity. The BL22 immunotoxin binds to CD22, an antigen expressed in B-cell malignancies, thereby delivering its toxin directly to tumor cells. The toxin induces caspase-mediated apoptosis of tumor cells in part through mechanisms involving mitochondrial damage. It also blocks translational extension by binding to elongation factor 2 in eukaryotic cells.
Indication
Hairy Cell Leukemia
Classification
Immuntoxin; biobetter
Construction
RFB4(dsFv)-PE38
Trade Name
CAT-3888
Synonyms
Anti-CD22 Recombinant Immunotoxin BL22; BL22; BL22 Immunotoxin [RFB4(dsFv) - PE38; RFB4(dsFv)-PE38 immunotoxin
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD22
Full Name
CD22 Molecule
Background
CD22 (CD22 Molecule) is a Protein Coding gene.
Diseases associated with CD22 include Refractory Hematologic Cancer and Refractory Hairy Cell Leukemia.
Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System.
Gene Ontology (GO) annotations related to this gene include carbohydrate binding.
An important paralog of this gene is SIGLEC1.
Alternative Names
CD22 Molecule; CD22 Antigen; Sialic Acid-Binding Ig-Like Lectin 2; B-Lymphocyte Cell Adhesion Molecule; T-Cell Surface Antigen Leu-14; SIGLEC-2;
Gene ID
Entrez Gene: 933
UniProt ID
UniProtKB: P20273
Antibody Clone
RFB4
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
dsFv
Antibody Indication
Hairy Cell Leukemia
Toxic Moiety
PE38
Organism
Pseudomonas aeruginosa
Family
Pseudomonas exotoxin A
Molecular Mass
38 kDa
Toxic MOA
PE38 is a 38 kDa truncated form of Pseudomonas exotoxin (PE) containing amino acids 253–364 and 381–613. Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. Vibrio cholerae produces a similar protein called Cholix toxin (Q5EK40). It inhibits elongation factor 2. This is achieved by ADP ribosylation of EF2 using NAD +. This then causes the extension of the polypeptide to stop. This mechanism is similar to diphtheria toxin.
