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Anti-CD19 Recombinant Immunotoxin HD37-dgA (HD37(IgG)-dgA) (CAT#: BioBet-IT011Z) Datasheet

Target
CD19
IT Type
Antibody-based IT
Description
The antitumor activities of immunotoxins (ITs) HD37-dgA was constructed with deglycosylated ricin A chain (dgA) and anti-CD19 (HD37) monoclonal antibody.
Indication
Refractory B-cell malignancies; B-cell Leukemia/Lymphoma
Classification
Immuntoxin; biobetter
Construction
HD37(IgG)-dgA

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD19
Full Name
CD19 Molecule
Background
CD19 (CD19 Molecule) is a Protein Coding gene.Diseases associated with CD19 include Immunodeficiency, Common Variable, 3 and Common Variable Immunodeficiency. Among its related pathways are RET signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include signal transducer activity, downstream of receptor.
Alternative Names
CD19 Molecule; B-Lymphocyte Surface Antigen B4; T-Cell Surface Antigen Leu-12; Differentiation Antigen CD19; CD19 Antigen; B-Lymphocyte Antigen CD19; CVID3; B4;
Gene ID
Entrez Gene: 930
UniProt ID
UniProtKB: P15391
Antibody Clone
HD37
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
IgG
Host
Mouse
Species Reactivity
Human
Antibody Indication
Refractory B-cell malignancies; B-cell Leukemia/Lymphoma
Toxic Moiety
Deglycosylated ricin A chain (dgA)
Organism
Ricinus communis (Castor bean)
Family
Ricin
Molecular Mass
30.1kDa
Toxic MOA
Deglycosylated ricin A chain (dgA) is an N-glycoside hydrolase composed of 267 amino acids. Ricin is a toxalbumin, a biological toxin whose mechanism of action is inhibition of protein synthesis (manufacture of proteins) in eukaryotic cells; cell death results from the absence of proteins.

The antibody portion mediated selective binding to target cells, while the toxin portion mediated translocation into the cytosol and subsequent cell killing.

Refractory B-cell malignancies; B-cell Leukemia/Lymphoma

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Anti-CD19 Recombinant Immunotoxin (4G7(scFv)-ETA) (CAT#: BioBet-IT013Z)
Anti-CD19 Recombinant Immunotoxin DT-AntiCD19 (DT390-FMC63(bi-scFv)) (CAT#: BioBet-IT010Z)

All products and services are for Research Use Only. Do Not use in humans.

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