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Anti-CD19 Recombinant Immunotoxin (B4-Ricin) (CAT#: BioBet-IT012Z) Datasheet

Target
CD19
IT Type
Antibody-based IT
Description
The immunotoxin includes a mouse anti-CD19 antibody (B4) coupled to a modified form of ricin (a phytotoxin). In multiple phase I and phase II studies of this immunotoxin, the desired response has been seen in many patients with tolerable and reversible toxicity.
Indication
Refractory B-cell malignancies; B-cell Leukemia/Lymphoma
Classification
Immuntoxin; biobetter
Construction
B4-Ricin

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD19
Full Name
CD19 Molecule
Background
CD19 (CD19 Molecule) is a Protein Coding gene.Diseases associated with CD19 include Immunodeficiency, Common Variable, 3 and Common Variable Immunodeficiency. Among its related pathways are RET signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include signal transducer activity, downstream of receptor.
Alternative Names
CD19 Molecule; B-Lymphocyte Surface Antigen B4; T-Cell Surface Antigen Leu-12; Differentiation Antigen CD19; CD19 Antigen; B-Lymphocyte Antigen CD19; CVID3; B4;
Gene ID
Entrez Gene: 930
UniProt ID
UniProtKB: P15391
Antibody Clone
B4
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
scFv
Host
Mouse
Species Reactivity
Human
Antibody Indication
Refractory B-cell malignancies; B-cell Leukemia/Lymphoma
Toxic Moiety
Ricin toxin A chain (RTA)
Organism
Ricinus communis (Castor bean)
Family
Ricin
Molecular Mass
30.1kDa
Toxic MOA
Ricin toxin A chain (RTA) is an N-glycoside hydrolase composed of 267 amino acids. Ricin is a toxalbumin, a biological toxin whose mechanism of action is inhibition of protein synthesis (manufacture of proteins) in eukaryotic cells; cell death results from the absence of proteins.

The antibody portion mediated selective binding to target cells, while the toxin portion mediated translocation into the cytosol and subsequent cell killing.

Refractory B-cell malignancies; B-cell Leukemia/Lymphoma

Related Products

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Anti-CD19 Recombinant Immunotoxin DT-AntiCD19 (DT390-FMC63(scFv)) (CAT#: BioBet-IT009Z)
Anti-CD19 Recombinant Immunotoxin (4G7(scFv)-ETA) (CAT#: BioBet-IT013Z)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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