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Anti-XCR1 Antibody, Non-Fucosylated (11H2) (CAT#: BioBet-1453ZP) Datasheet

Target
XCR1
Isotype
IgG
Description
ADCC-Enhanced anti-XCR1 (11H2) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Autoimmune Diseases
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced XCR1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
XCR1
Full Name
chemokine (C motif) receptor 1
Background
The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Alternative Names
XCR1; chemokine (C motif) receptor 1; GPR5; CCXCR1; chemokine XC receptor 1; lymphotactin receptor; XC chemokine receptor 1; G protein-coupled receptor 5; G-protein coupled receptor 5; chemokine (C motif) XC receptor 1
Gene ID
2829
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with XCR1 include Leber Plus Disease.
Related Pathways
Its related pathways are RET signaling and Signaling by GPCR.
Function
Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin.
Post-translational modifications
1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
11H2
Host
Humanized
Species Reactivity
Human
Description
The antibody that binds to human XCR1 can be used for various immune diseases including autoimmune diseases.
Antibody Indication
Autoimmune Diseases

Autoimmune Diseases

Related Products

Anti-XCR1 Antibody, Non-Fucosylated (2H6) (CAT#: BioBet-1451ZP)
Anti-XCR1 Antibody, Non-Fucosylated (5G7) (CAT#: BioBet-1452ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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