Anti-Tissue Factor Antibody, Non-Fucosylated (MORAb-066) (CAT#: BioBet-854ZP) Datasheet

F3

coagulation factor III (thromboplastin, tissue factor)

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.

F3; coagulation factor III (thromboplastin, tissue factor); TF; TFA; CD142; tissue factor

Extracellular region or secreted

Diseases associated with F3 include Disseminated Intravascular Coagulation and Carotid Artery Thrombosis.

Its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Response to elevated platelet cytosolic Ca2+.

By forming a complex with circulating factor VII or VIIa, blood coagulation is initiated. [TF:VIIa] The complex activates factor IX or X through specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell surface assembly and proliferation of the coagulation protease cascade.

1.Glycosylation at Asn156 and Asn169 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

MORAb-066

Humanized

Human

MORAb-066 is a humanized monoclonal antibody that targets tissue factor (TF), which is a protein whose role under normal conditions is to support blood coagulation. In cancer, it has been shown that TF is a membrane-bound antigen expressed by tumor endothelial cells that is hypothesized to play a role in promoting tumor angiogenesis and growth.

Pancreatic Cancer

Pancreatic Cancer