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Anti-RTN4 Antibody, Non-Fucosylated (CAT#: BioBet-432ZP) Datasheet

Target
RTN4
Isotype
IgG4, κ
Description
Anti-RTN4 Antibody, Non-Fucosylated (BioBet-432ZP) is a human monoclonal IgG4, κ antibody against RTN4. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Spinal cord injury, acute
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced RTN4 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
RTN4
Full Name
Reticulon 4
Background
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Alternative Names
Atinumab; 1226761-65-4; ATI355; RTN4; reticulon 4; reticulon-4; ASY; KIAA0886; NOGO; NSP CL; foocen; Human NogoA; reticulon 5; My043 protein; neurite outgrowth inhibitor; neurite growth inhibitor 220; neuroendocrine-specific protein C homolog; NSP; NOGOC; RTN-X; NOGO-A; NSP-C
Gene ID
57142
UniProt ID
Q9NQC3
Cellular Localization
Plasma membrane, Endoplasmic reticulum
Involvement in Disease
Diseases associated with RTN4 include Kleptomania and Temporal Lobe Epilepsy.
Related Pathways
Its related pathways are Neuroscience and Signaling by GPCR.
Function
Induces the formation and stability of endoplasmic reticulum (ER) tubules. They regulate the formation of endoplasmic reticulum membrane by promoting the production of endoplasmic reticulum ducts. They affect the expansion of the nuclear membrane, the formation of nuclear pore complexes and the proper positioning of proteins in the nuclear membrane. However, each isomer has a specific function, mainly depending on their tissue expression specificity (possibly).
Field of research
Neuroscience antibody
Post-translational modifications
N-glycosylated. O-glycosylated. Contains terminal sialic acid groups on its glycan chains.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG4, κ
Antibody Clone
BioBet-432ZP
Host
Human
Species Reactivity
Human
Description
ADCC-enhanced Atinumab is a non-fucosylated anti-RTN4 therapeutic biobetter antibody.
Antibody Indication
Spinal cord injury, acute

Spinal cord injury, acute

Related Products

Anti-RTN4 Antibody, Highly Galactosylated (CAT#: BioBet-GA-432ZP)
Anti-RTN4 Antibody, On-Target (CAT#: AES-0622-ZP685)
Anti-RTN4 Antibody, FcγRIIB Binding Enhanced (CAT#: AES-0622-ZP357)
Anti-RTN4 Antibody, Half-Life Extended (CAT#: AES-0622-ZP1013)
Anti-RTN4 Antibody, Recycling (CAT#: AES-0622-ZP29)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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