Anti-Rat C5b-9 Monoclonal Antibody (clone 2A1) -10 mg (CAT#: CB-P441-AB) Datasheet

Product Type
Antibody
Description
Monoclonal antibody 2A1 recognizes rat C5b-9. It shows that this antibody competes with human C9 antibody for its binding site in the C5b-9 complex, indicating that the reactive epitope is located on the C9 molecule. C5b-9 membrane attack is caused by serum The five precursor molecules in assemble the complex, C5 convertase proteolytically cleaves C5 to generate C5b, thereby initiating the assembly of the C5b-9 complex; the last step in the formation of the C5b-9 complex involves the polymerization of C9, accompanied by The complex is inserted during the polymerization reaction of C5b-8 and C9 to produce new antigens, which are unique to the C5b-9 complex and are not present in any single natural complex component. Complement regulatory protein CD59 and complement S protein can prevent C5b-9 from inserting into the cell membrane by both, and the formed SC5b-9 complex cannot attach to cells and has no cytolytic activity. Treat teinuric nephropathy by regulating continuous tubulointerstitial damage. Abolish C5b- After the 9 complex is formed, it can improve the early tubular interstitial damage of the remaining kidney.
Produce monoclonal antibody 2A1 against rat C5b-9 neoantigen. The monoclonal antibody 2A1 can be used as a coating antibody to detect C5b-9 in plasma and urine samples.
Disease
Infectious diseases, Nephrology
Size
100 µg
Immunogen
Rat C5b-9
Species
Rat
Host
Mouse
Clonality
Monoclonal
Isotype
Mouse IgG1
Clone Number
2A1
Buffer
PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
Application
Flow cytometry, Frozen sections, Immuno assays, Immuno fluorescence, Paraffin sections, Western blot
Application Notes
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
Storage Instructions
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Target
C5b-9
Alternative Names
Membrane attack complex; MAC; TCC; Terminal Complement Complex

All products and services are for Research Use Only. Do Not use in humans.

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